Evidence map›Paper›PMID 28966648›Full record

ArticleNeural regeneration research2017

Cold water swimming pretreatment reduces cognitive deficits in a rat model of traumatic brain injury.

Zi-Wei Zhou, Ya-Dan Li, Wei-Wei Gao, Jie-Li Chen, Shu-Yuan Yue, Jian-Ning Zhang

Abstract read
In one paragraph

Article in Neural regeneration research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Neural regeneration research · 2018
    Article
  3. Resveratrol Attenuates Cognitive Deficits of Traumatic Brain Injury by Activating p38 Signaling in the Brain.Medical science monitor : international medical journal of experimental and clinical research · 2018
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Zi-Wei ZhouDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.ORCID 0000-0002-5927-7835
Ya-Dan LiIntensive Care Units, Tianjin Huanhu Hospital, Tianjin, China.
Wei-Wei GaoDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
Jie-Li ChenDepartment of Neurology, Henry Ford Hospital, Detroit, MI, USA.
Shu-Yuan YueDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.
Jian-Ning ZhangDepartment of Neurosurgery, Tianjin Medical University General Hospital, Tianjin, China.ORCID 0000-0002-7290-0994

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A moderate stress such as cold water swimming can raise the tolerance of the body to potentially injurious events. However, little is known about the mechanism of beneficial effects induced by moderate stress. In this study, we used a classic rat model of traumatic brain injury to test the hypothesis that cold water swimming preconditioning improved the recovery of cognitive functions and explored the mechanisms. Results showed that after traumatic brain injury, pre-conditioned rats (cold water swimming for 3 minutes at 4°C) spent a significantly higher percent of times in the goal quadrant of cold water swim, and escape latencies were shorter than for non-pretreated rats. The number of circulating endothelial progenitor cells was significantly higher in pre-conditioned rats than those without pretreatment at 0, 3, 6 and 24 hours after traumatic brain injury. Immunohistochemical staining and Von Willebrand factor staining demonstrated that the number of CD34

Indexed as

angiogenesisCD34cognitive deficitscold water swimmingendothelial progenitor cellsfluid percussion injury modelMorris water mazenerve regenerationneural regenerationneural repairstressVon Willebrand factor

Identifiers

PMID28966648
PMCPMC5607828

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.