Evidence map›Paper›PMID 28966594›Full record

ReviewFrontiers in physiology2017

The Role of the Autonomic Nervous System in the Pathophysiology of Obesity.

Daniela Guarino, Monica Nannipieri, Giorgio Iervasi, Stefano Taddei, Rosa Maria Bruno

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Frontiers in physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04029532 (Factors Associated With Obesity in Adult Women), which is not on this map. Cited by 131 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
131citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04029532 completednot on this mapstarted 2019, after this paper: background citation

Factors Associated With Obesity in Adult Women: Respiratory Exchange Ratio, Heart Rate Variation and Body Image

TypeobservationalSponsorNational Taiwan University HospitalRan2019 to 2020Enrolled121ConditionsObesityArmsRespiratory exchange ratio, Heart rate variability, Body composition, Eating behavior, Physical activity recall
3 · Its place in the literature

Who cites it

131 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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  3. Maternal obesity in pregnancy impacts offspring cardiometabolic health: Systematic review and meta-analysis of animal studies.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2019
    Pooled it
  4. Trial
  5. Effects of weight loss and weight loss maintenance on cardiac autonomic function in obesity: a randomized controlled trial.Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme · 2023
    Trial
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  18. Phenomenon of hypocortisolism in individuals with obesity.Comprehensive psychoneuroendocrinology · 2025
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  20. Article

71 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Daniela GuarinoDepartment of Clinical and Experimental Medicine, University of PisaPisa, Italy.
Monica NannipieriDepartment of Clinical and Experimental Medicine, University of PisaPisa, Italy.
Giorgio IervasiInstitute of Clinical Physiology of CNRPisa, Italy.
Stefano TaddeiDepartment of Clinical and Experimental Medicine, University of PisaPisa, Italy.
Rosa Maria BrunoDepartment of Clinical and Experimental Medicine, University of PisaPisa, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Obesity is reaching epidemic proportions globally and represents a major cause of comorbidities, mostly related to cardiovascular disease. The autonomic nervous system (ANS) dysfunction has a two-way relationship with obesity. Indeed, alterations of the ANS might be involved in the pathogenesis of obesity, acting on different pathways. On the other hand, the excess weight induces ANS dysfunction, which may be involved in the haemodynamic and metabolic alterations that increase the cardiovascular risk of obese individuals, i.e., hypertension, insulin resistance and dyslipidemia. This article will review current evidence about the role of the ANS in short-term and long-term regulation of energy homeostasis. Furthermore, an increased sympathetic activity has been demonstrated in obese patients, particularly in the muscle vasculature and in the kidneys, possibily contributing to increased cardiovascular risk. Selective leptin resistance, obstructive sleep apnea syndrome, hyperinsulinemia and low ghrelin levels are possible mechanisms underlying sympathetic activation in obesity. Weight loss is able to reverse metabolic and autonomic alterations associated with obesity. Given the crucial role of autonomic dysfunction in the pathophysiology of obesity and its cardiovascular complications, vagal nerve modulation and sympathetic inhibition may serve as therapeutic targets in this condition.

Indexed as

adipose tissueautonomic nervous systemenergy expendituregut hormonesobesityvagal nerve blockadevagal nerve stimulationweight loss

Identifiers

PMID28966594
PMCPMC5606212

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.