Evidence map›Paper›PMID 28966516›Full record

ArticleAnnals of dermatology2017

Comprehensive Transcriptome Profiling of Balding and Non-Balding Scalps in Trichorhinophalangeal Syndrome Type I Patient.

Yun-Ji Kim, Byulee Yoon, Kyudong Han, Byung Cheol Park

Open access · hybridAbstract read
In one paragraph

Article in Annals of dermatology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Yun-Ji KimTheragenETEX Bio Institute, TheragenETEX Inc., Suwon, Korea.
Byulee YoonDepartment of Nanobiomedical Science, Dankook University, Cheonan, Korea.
Kyudong HanDepartment of Nanobiomedical Science, Dankook University, Cheonan, Korea.
Byung Cheol ParkDepartment of Dermatology, Dankook University Medical College, Cheonan, Korea.
Dankook University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTrichorhinophalangeal syndrome (TRPS) patients tend to have alopecia that appears to be androgenetic, and this genetic model might give clues to the pathogenesis of hair loss or hair morphogenesis.

objectiveThis study was conducted to identify additional genetic evidence of TRPS and hair morphogenesis from a TRPS patient.

methodsFrom one TRPS type I patient, we extracted RNA and profiled whole transcriptome in non-balding and balding scalp areas using high-throughput RNA sequencing.

resultsWe found a total of 26,320 genes, which comprised 14,892 known genes with new isoforms and 4,883 novel genes from the non-balding and balding areas. Among these, a total of 1,242 genes showed different expression in the two scalp areas (

conclusionOur result could suggest a novel perspective and evidence to support further study of TRPS and hair morphogenesis.

Indexed as

Androgenetic alopeciaDifferentially expressed geneTranscriptomeTrichorhinophalangeal syndromeTRPS1

Identifiers

PMID28966516
PMCPMC5597653
OpenAlexW2756053167

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.