ArticleHistochemistry1988
Heterogenous staining of D-amino acid oxidase in peroxisomes of rat liver and kidney. A light and electron microscopic study.
Article in Histochemistry, 1988. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 74 citations in OpenAlex.
- Variability in intracellular localization of D-amino acid oxidase in choroid plexus epithelial cells.The FEBS journal · 2026Article
- A brief history of the human liver peroxisome.Histochemistry and cell biology · 2026Review
- Peroxisomal core structures segregate diverse metabolic pathways.Nature communications · 2025Article
- Distinct peroxisome populations differentially respond to alcohol-associated hepatic injury.Molecular biology of the cell · 2024Article
- The peroxisome: an update on mysteries 2.0.Histochemistry and cell biology · 2018Review
- Transient complex peroxisomal interactions: A new facet of peroxisome dynamics in mammalian cells.Communicative & integrative biology · 2012Article
- Peroxisomes and reactive oxygen species, a lasting challenge.Histochemistry and cell biology · 2009Review
- Immunohistochemical distribution of activated nuclear factor kappaB and peroxisome proliferator-activated receptors in carbon tetrachloride-induced chronic liver injury in rats.Histochemistry and cell biology · 2005Article
- Mammalian peroxisomes and reactive oxygen species.Histochemistry and cell biology · 2004Review
- Multiple targeting modules on peroxisomal proteins are not redundant: discrete functions of targeting signals within Pmp47 and Pex8p.Molecular biology of the cell · 2004Article
- Contributions of the immunogold technique to investigation of the biology of peroxisomes.Histochemistry and cell biology · 1996Review
- In situ heterogeneity of peroxisomal oxidase activities: an update.The Histochemical journal · 1996Review
- Reflectance enzyme histochemistry (REH): visualization of cerium-based and DAB primary reaction products of phosphatases and oxidases in cryostat sections by confocal laser scanning microscopy.Histochemistry and cell biology · 1996Article
- Extinction coefficient of polymerized diaminobenzidine complexed with cobalt as final reaction product of histochemical oxidase reactions.Histochemistry and cell biology · 1995Article
- Localization of dihydroorotate oxidase in myocardium and kidney cortex of the rat. An electron microscopic study using the cerium technique.Histochemistry and cell biology · 1995Article
- In situ kinetic measurements of D-amino acid oxidase in rat liver with respect to its substrate specificity.The Histochemical journal · 1993Article
- Biogenesis of peroxisomes: isolation and characterization of two distinct peroxisomal populations from normal and regenerating rat liver.The Journal of cell biology · 1993Article
- Histochemistry of peroxisomal enzyme activities: a tool in the diagnosis of Zellweger syndrome.Journal of inherited metabolic disease · 1993Article
- Peroxisomes in guinea pig liver: their peculiar morphological features may reflect certain aspects of lipoprotein metabolism in this species.Cell and tissue research · 1991Article
- Pitfalls in the light microscopical detection of NADH oxidase.The Histochemical journal · 1990Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The localization of D-amino acid oxidase (D-AAOX) in rat liver and kidney has been investigated using the cerium technique for electron microscopy and a recent modification of it for light microscopy. In the liver a mosaic pattern with strongly and weakly stained cells together with some completely negative hepatocytes is observed. The staining is stronger and more uniform in periportal than in perivenous regions of the liver lobule. In the kidney the reaction is confined to the proximal tubules of the renal cortex with the rest of the nephron being negative. At the ultrastructural level in both liver and kidney a marked heterogeneity is observed in the intensity of reaction in peroxisomes of some neighbouring cells. Moreover, in some cells heavily and weakly stained peroxisomes are seen side by side. When Pipes buffer is used in the incubation medium the D-AAOX reaction in kidney peroxiosomes is aggregated in the central region of the matrix with weaker staining of the periphery. A similar result is obtained when the enzyme is localized by immunocytochemistry confirming a recent report by Usuda et al. (1986). The heterogeneous staining of peroxisomes for D-AAOX suggests that subpopulations of this organelle with specialized functions may exist not only in different tissues and cells but even within the same cell.
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2896644W59225159What OpenQuestion holds
Registered trials
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