ArticleJournal Of Elasticity2017
Multi-Scale Modeling of Vision-Guided Remodeling and Age-Dependent Growth of the Tree Shrew Sclera During Eye Development and Lens-Induced Myopia.
Article in Journal Of Elasticity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed, 25 citations in OpenAlex.
- Axial length changes and baseline predictors over five years in children treated with orthokeratology lenses: a retrospective cohort study.Frontiers in bioengineering and biotechnology · 2026Article
- Association between first-year axial elongation and 10-year myopia progression in children wearing orthokeratology lenses: a ten-year longitudinal study.Frontiers in cell and developmental biology · 2026Article
- Microindentation reveals softening of the equatorial and anterior sclera during early myopia development in tree shrew eyes.Acta biomaterialia · 2025Article
- Biomechanical changes of tree shrew posterior sclera during experimental myopia, after retrobulbar vehicle injections, and crosslinking using genipin.Scientific reports · 2024Article
- Collagen is crucial target protein for scleral remodeling and biomechanical change in myopia progression and control.Heliyon · 2024Review
- Altered Structure and Function of Murine Sclera in Form-Deprivation Myopia.Investigative ophthalmology & visual science · 2022Article
- Scleral crosslinking using genipin can compromise retinal structure and function in tree shrews.Experimental eye research · 2022Article
- Effect of different preconditioning protocols on the viscoelastic inflation response of the posterior sclera.Acta biomaterialia · 2021Article
- Effect of Scleral Crosslinking Using Multiple Doses of Genipin on Experimental Progressive Myopia in Tree Shrews.Translational vision science & technology · 2021Article
- Connective Tissue Remodeling in Myopia and its Potential Role in Increasing Risk of Glaucoma.Current opinion in biomedical engineering · 2020Article
- Scleral structure and biomechanics.Progress in retinal and eye research · 2020Review
- Article
- Matching the LenStar optical biometer to A-Scan ultrasonography for use in small animal eyes with application to tree shrews.Experimental eye research · 2019Article
- Gene expression signatures in tree shrew sclera during recovery from minus-lens wear and during plus-lens wear.Molecular vision · 2019Article
- Spatial Patterns and Age-Related Changes of the Collagen Crimp in the Human Cornea and Sclera.Investigative ophthalmology & visual science · 2018Article
- Experimental myopia increases and scleral crosslinking using genipin inhibits cyclic softening in the tree shrew sclera.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2018Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The sclera uses unknown mechanisms to match the eye's axial length to its optics during development, producing eyes with good focus (emmetropia). A myopic eye is too long for its own optics. We propose a multi-scale computational model to simulate eye development based on the assumption that scleral growth is controlled by genetic factors while scleral remodeling is driven by genetic factors and the eye's refractive error. We define growth as a mechanism that changes the tissue volume and mass while remodeling involves internal micro-deformations that are volume-preserving at the macroscale. The model was fitted against longitudinal refractive measurements in tree shrews of different ages and exposed to three different visual conditions: (i) normal development; (ii) negative lens wear to induce myopia; and (iii) recovery from myopia by removing the negative lens. The model was able to replicate the age- and vision-dependent response of the tree shrew experiments. Scleral growth ceased at younger age than scleral remodeling. The remodeling rate decreased as the eye emmetropized but increased at any age when a negative lens was put on. The predictive power of the model was investigated by calculating the susceptibility to scleral remodeling and the response to form deprivation myopia in tree shrews. Both predictions were in good agreement with experimental data that were not used to fit the model. We propose the first model that distinguishes scleral growth from remodeling. The good agreement of our results with experimental data supports the notion that scleral growth and scleral remodeling are two independently controlled mechanisms during eye development.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.