Evidence map›Paper›PMID 28966119›Full record

ArticleStem cell reports2017

WT1 Is Necessary for the Proliferation and Migration of Cells of Renin Lineage Following Kidney Podocyte Depletion.

Natalya V Kaverina, Diana G Eng, Andrea D Largent, Ilse Daehn, Anthony Chang, Kenneth W Gross, Jeffrey W Pippin, Peter Hohenstein, Stuart J Shankland

Open access · goldAbstract read
In one paragraph

Article in Stem cell reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 30 citations in OpenAlex.

  1. iScience · 2026
    Article
  2. Injury-induced paracrine effects on the podocyte's transcriptome.American journal of physiology. Renal physiology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. WT1Theranostics · 2023
    Article
  9. Mechanisms of podocyte injury and implications for diabetic nephropathy.Clinical science (London, England : 1979) · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Cells of NG2 lineage increase in glomeruli of mice following podocyte depletion.American journal of physiology. Renal physiology · 2018
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Natalya V KaverinaDivision of Nephrology, University of Washington School of Medicine, 750 Republican Street, Seattle, WA 98109, USA.
Diana G EngDivision of Nephrology, University of Washington School of Medicine, 750 Republican Street, Seattle, WA 98109, USA.
Andrea D LargentDivision of Nephrology, University of Washington School of Medicine, 750 Republican Street, Seattle, WA 98109, USA.
Ilse DaehnDepartment of Medicine, Division of Nephrology, The Icahn School of Medicine at Mount Sinai, 1468 Madison Avenue, New York, NY 10029, USA.
Anthony ChangDepartment of Pathology, University of Chicago, 5841 S Maryland Ave, Chicago, IL 60637, USA.
Kenneth W GrossDepartment of Molecular and Cellular Biology, Roswell Park Cancer Institute, Elm & Carlton Streets, Buffalo, NY 14263, USA.
Jeffrey W PippinDivision of Nephrology, University of Washington School of Medicine, 750 Republican Street, Seattle, WA 98109, USA.
Peter HohensteinThe Roslin Institute, University of Edinburgh, Easter Bush, Midlothian EH25 9RG, UK.
Stuart J ShanklandDivision of Nephrology, University of Washington School of Medicine, 750 Republican Street, Seattle, WA 98109, USA. Electronic address: stuartjs@uw.edu.
University of Washington · USIcahn School of Medicine at Mount Sinai · USRoswell Park Comprehensive Cancer Center · USUniversity of Chicago · USUniversity of Edinburgh · GB

Funding

Two-Spirit Films in Indigenous Cancer HealthP30CA016056 · NCI · ROSWELL PARK CANCER INSTITUTE CORP · PI Dean G. Tang · 1985 to 2026
$116.6M
Vector and Transgenic Mouse CoreP30DK017047 · NIDDK · UNIVERSITY OF WASHINGTON · PI Karin E Bornfeldt · 1986 to 2026
$41.4M
Juxta-glomerular cells serve as glomerular epithelial cell progenitors in glomerular diseaseR01DK097598 · NIDDK · UNIVERSITY OF WASHINGTON · PI SHANKLAND, STUART JAMES, WESSELY, OLIVER · 2014 to 2022
$5.2M
CELL CYCLE PROTEINS AND GLOMERULAR APOPTOSISR01DK056799 · NIDDK · UNIVERSITY OF WASHINGTON · PI SHANKLAND, STUART JAMES · 2000 to 2014
$3.6M
Reduced Glomerular Progenitors Impair Regeneration in Aged KidneyR01AG046231 · NIA · UNIVERSITY OF WASHINGTON · PI SHANKLAND, STUART JAMES · 2016 to 2020
$2.6M
Pericyte-endothelial cross talk in vascular stability after kidney injuryR01DK093493 · NIDDK · UNIVERSITY OF WASHINGTON · PI SHANKLAND, STUART JAMES · 2012 to 2016
$2.5M
CELL CYCLE CONTROL IN GLOMERULAR DISEASER01DK051096 · NIDDK · UNIVERSITY OF WASHINGTON · PI SHANKLAND, STUART JAMES · 1997 to 2007
$1.8M
Medical Research Council MR/M010341/1NCI NIH HHS P30 CA016056NIA NIH HHS R01 AG046231NIDDK NIH HHS P30 DK017047NIDDK NIH HHS R01 DK051096NIDDK NIH HHS R01 DK056799NIDDK NIH HHS R01 DK093493NIDDK NIH HHS R01 DK097598
6 · The paper itself

Abstract

Wilms' tumor suppressor 1 (WT1) plays an important role in cell proliferation and mesenchymal-epithelial balance in normal development and disease. Here, we show that following podocyte depletion in three experimental models, and in patients with focal segmental glomerulosclerosis (FSGS) and membranous nephropathy, WT1 increased significantly in cells of renin lineage (CoRL). In an animal model of FSGS in RenWt1

Indexed as

Cell LineageAnimalsBiomarkersCell MovementCell ProliferationDisease Models, AnimalGene DeletionKidney Function TestsKidney GlomerulusMiceMice, KnockoutPodocytesReninWT1 ProteinsBiomarkersReninWT1 ProteinsenalaprilFSGSglomerulusmembranous nephropathymesenchymal-to-epithelial transformationMETp57progenitorregenerationsynaptopodin

Identifiers

PMID28966119
PMCPMC5639431
OpenAlexW2757995124

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.