Evidence map›Paper›PMID 28965876›Full record

ArticleEBioMedicine2017

Microbiota-related Changes in Bile Acid & Tryptophan Metabolism are Associated with Gastrointestinal Dysfunction in a Mouse Model of Autism.

Anna V Golubeva, Susan A Joyce, Gerard Moloney, Aurelijus Burokas, Eoin Sherwin, Silvia Arboleya, Ian Flynn, Dmitry Khochanskiy, Angela Moya-Pérez, Veronica Peterson and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in EBioMedicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 190 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
190citing papers in PubMed, 4 pooled it
10.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

190 citing papers in PubMed, 4 syntheses or guidelines pooled it, 355 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Comparing the Gut Microbiome in Autism and Preclinical Models: A Systematic Review.Frontiers in cellular and infection microbiology · 2022
    Pooled it
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130 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 2 countries.

Anna V GolubevaAPC Microbiome Institute, University College Cork, Cork, Ireland.
Susan A JoyceAPC Microbiome Institute, University College Cork, Cork, Ireland; School of Biochemistry & Cell Biology, University College Cork, Cork, Ireland.
Gerard MoloneyDepartment of Anatomy & Neuroscience, University College Cork, Cork, Ireland.
Aurelijus BurokasAPC Microbiome Institute, University College Cork, Cork, Ireland.
Eoin SherwinAPC Microbiome Institute, University College Cork, Cork, Ireland.
Silvia ArboleyaAPC Microbiome Institute, University College Cork, Cork, Ireland; Teagasc Food Research Centre, Moorepark Fermoy, County Cork, Ireland.
Ian FlynnDepartment of Anatomy & Neuroscience, University College Cork, Cork, Ireland.
Dmitry KhochanskiyResearch Institute of Human Morphology, Moscow, Russia.
Angela Moya-PérezAPC Microbiome Institute, University College Cork, Cork, Ireland.
Veronica PetersonAPC Microbiome Institute, University College Cork, Cork, Ireland.
Kieran ReaAPC Microbiome Institute, University College Cork, Cork, Ireland.
Kiera MurphyTeagasc Food Research Centre, Moorepark Fermoy, County Cork, Ireland.
Olga MakarovaResearch Institute of Human Morphology, Moscow, Russia; Lomonosov Moscow State University, Moscow, Russia.
Sergey BuravkovResearch Institute of Human Morphology, Moscow, Russia; Lomonosov Moscow State University, Moscow, Russia.
Niall P HylandAPC Microbiome Institute, University College Cork, Cork, Ireland; Department of Pharmacology & Therapeutics, University College Cork, Cork, Ireland.
Catherine StantonAPC Microbiome Institute, University College Cork, Cork, Ireland; Teagasc Food Research Centre, Moorepark Fermoy, County Cork, Ireland; Department of Psychiatry & Neurobehavioural Sciences, University College Cork, Cork, Ireland.
Gerard ClarkeAPC Microbiome Institute, University College Cork, Cork, Ireland; Department of Psychiatry & Neurobehavioural Sciences, University College Cork, Cork, Ireland.
Cormac G M GahanAPC Microbiome Institute, University College Cork, Cork, Ireland; School of Microbiology, University College Cork, Cork, Ireland.
Timothy G DinanAPC Microbiome Institute, University College Cork, Cork, Ireland; Department of Psychiatry & Neurobehavioural Sciences, University College Cork, Cork, Ireland.
John F CryanAPC Microbiome Institute, University College Cork, Cork, Ireland; Department of Anatomy & Neuroscience, University College Cork, Cork, Ireland. Electronic address: j.cryan@ucc.ie.
University College Cork · IETeagasc - The Irish Agriculture and Food Development Authority · IELomonosov Moscow State University · RUResearch Institute of Human Morphology · RU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism spectrum disorder (ASD) is one of the most prevalent neurodevelopmental conditions worldwide. There is growing awareness that ASD is highly comorbid with gastrointestinal distress and altered intestinal microbiome, and that host-microbiome interactions may contribute to the disease symptoms. However, the paucity of knowledge on gut-brain axis signaling in autism constitutes an obstacle to the development of precision microbiota-based therapeutics in ASD. To this end, we explored the interactions between intestinal microbiota, gut physiology and social behavior in a BTBR T

Indexed as

AnimalsAutism Spectrum DisorderBacteriaBifidobacteriumBile Acids and SaltsDisease Models, AnimalGastrointestinal DiseasesGastrointestinal TractGene Expression ProfilingGene Expression RegulationGene Regulatory NetworksMaleMiceMicrobiotaTryptophanBile Acids and SaltsTryptophanAutismBile acidsBTBR mouseGut microbiotaIntestinal permeabilityIntestinal transitSerotoninTryptophan

Identifiers

PMID28965876
PMCPMC5652137
OpenAlexW2759256625

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.