ArticleMolecular plant2017
Initiation of ER Body Formation and Indole Glucosinolate Metabolism by the Plastidial Retrograde Signaling Metabolite, MEcPP.
Article in Molecular plant, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 36 citations in OpenAlex.
- Chloroplast Stress Signals Orchestrate Epidermis-Specific Remodeling of Mitochondria and ER Under High Light.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Metabolite control of enzyme activity links stress to biosynthetic regulation.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Plastids in a Pinch: Coordinating Stress and Developmental Responses Through Retrograde Signalling.Plant, cell & environment · 2025Review
- Glucosinolates can act as signals to modulate intercellular trafficking via plasmodesmata.The New phytologist · 2025Article
- Information-incorporated gene network construction with FDR control.Bioinformatics (Oxford, England) · 2024Article
- Plant photoreceptors and their signalling components in chloroplastic anterograde and retrograde communication.Journal of experimental botany · 2022Article
- Integrated omics reveal novel functions and underlying mechanisms of the receptor kinase FERONIA in Arabidopsis thaliana.The Plant cell · 2022Article
- Reciprocity between a retrograde signal and a putative metalloprotease reconfigures plastidial metabolic and structural states.Science advances · 2022Article
- Cesium tolerance is enhanced by a chemical which binds to BETA-GLUCOSIDASE 23 in Arabidopsis thaliana.Scientific reports · 2021Article
- Evolutionary analysis of the Moringa oleifera genome reveals a recent burst of plastid to nucleus gene duplications.Scientific reports · 2020Article
- Retrograde Induction of phyB Orchestrates Ethylene-Auxin Hierarchy to Regulate Growth.Plant physiology · 2020Article
- Chloroplast-associated molecular patterns as concept for fine-tuned operational retrograde signalling.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2020Review
- Uncovering the functional residues ofProceedings of the National Academy of Sciences of the United States of America · 2020Article
- Orthogonal regulation of phytochrome B abundance by stress-specific plastidial retrograde signaling metabolite.Nature communications · 2019Article
- A Family of NAI2-Interacting Proteins in the Biogenesis of the ER Body and Related Structures.Plant physiology · 2019Article
- Interplay of the two ancient metabolites auxin and MEcPP regulates adaptive growth.Nature communications · 2018Article
- Malate transported from chloroplast to mitochondrion triggers production of ROS and PCD in Arabidopsis thaliana.Cell research · 2018Article
Corrections and comments
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Authors and funding
15 authors at 4 institutions in 2 countries.
Funding
Abstract
Plants have evolved tightly regulated signaling networks to respond and adapt to environmental perturbations, but the nature of the signaling hub(s) involved have remained an enigma. We have previously established that methylerythritol cyclodiphosphate (MEcPP), a precursor of plastidial isoprenoids and a stress-specific retrograde signaling metabolite, enables cellular readjustments for high-order adaptive functions. Here, we specifically show that MEcPP promotes two Brassicaceae-specific traits, namely endoplasmic reticulum (ER) body formation and induction of indole glucosinolate (IGs) metabolism selectively, via transcriptional regulation of key regulators NAI1 for ER body formation and MYB51/122 for IGs biosynthesis). The specificity of MEcPP is further confirmed by the lack of induction of wound-inducible ER body genes as well as IGs by other altered methylerythritol phosphate pathway enzymes. Genetic analyses revealed MEcPP-mediated COI1-dependent induction of these traits. Moreover, MEcPP signaling integrates the biosynthesis and hydrolysis of IGs through induction of nitrile-specifier protein1 and reduction of the suppressor, ESM1, and production of simple nitriles as the bioactive end product. The findings position the plastidial metabolite, MEcPP, as the initiation hub, transducing signals to adjust the activity of hard-wired gene circuitry to expand phytochemical diversity and alter the associated subcellular structure required for functionality of the secondary metabolites, thereby tailoring plant stress responses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.