Evidence map›Paper›PMID 28965796›Full record

ArticleJournal of infection and public health

Dried blood spots: An evaluation of utility in the field.

Xu Su, Bradley F Carlson, Xiexiu Wang, Xiaoyan Li, Ying Zhang, JoLynn P Montgomery, Yaxing Ding, Abram L Wagner, Brenda Gillespie, Matthew L Boulton

Open access · goldAbstract readEvaluation Study
In one paragraph

Article in Journal of infection and public health. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 30 citations in OpenAlex.

  1. Observational
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  3. An Expert Consensus Statement on Biomarkers of Aging for Use in Intervention Studies.The journals of gerontology. Series A, Biological sciences and medical sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Xu SuTianjin Centers for Disease Control and Prevention, Tianjin 300011, People's Republic of China.
Bradley F CarlsonDepartment of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA.
Xiexiu WangTianjin Centers for Disease Control and Prevention, Tianjin 300011, People's Republic of China.
Xiaoyan LiTianjin Centers for Disease Control and Prevention, Tianjin 300011, People's Republic of China.
Ying ZhangTianjin Centers for Disease Control and Prevention, Tianjin 300011, People's Republic of China.
JoLynn P MontgomeryDepartment of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA.
Yaxing DingTianjin Centers for Disease Control and Prevention, Tianjin 300011, People's Republic of China.
Abram L WagnerDepartment of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA.
Brenda GillespieDepartment of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA.
Matthew L BoultonDepartment of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA; Department of Internal Medicine, Division of Infectious Diseases, University of Michigan, MI 48109, USA. Electronic address: mboulton@umich.edu.
Tianjin Centers for Disease Control and Prevention · CNUniversity of Michigan · US

Funding

International Collaborations in Infectious Disease Research (ICIDR) (U01)U01AI088671 · NIAID · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BOULTON, MATTHEW LESTER · 2010 to 2014
$3.6M
NIAID NIH HHS U01 AI088671
6 · The paper itself

Abstract

backgroundUse of dried blood spots (DBS) offers advantages over serum samples in studies conducted in resource-poor settings. The aim of this study was to compare the number of adequate spots collected across different demographic groups.

methodsFive DBS were collected from 3316 individuals aged 0-49 years in Tianjin, China for a measles antibody study; DBS were rated "adequate" or "inadequate." Linear regression, with the number of adequate DBS on a card as the outcome variable, was used to test for predictors of DBS adequacy.

resultsThere were 0 adequate DBS for 23% of participants and 5 adequate DBS for 24%. Mean number of adequate DBS was 1.68 in infants (<12 months), 2.57 (1-9 years), 3.49 (10-29 years), 3.08 (30-49 years). The number of adequate DBS increased over the study; the mean number of adequate DBS for the five years 2011-2015 were 1.21, 2.52, 3.40, 2.22, and 3.62, respectively. DBS quality was not related to measles IgG antibodies.

conclusionsDBS are an alternative for adults and children but pose challenges in infants, and improve with experience. In a resource-limited environment or in a scenario where more invasive techniques like venipuncture may be less accepted by the study population, DBS can be the preferred technique to efficiently obtain serum specimens for analyte testing.

Indexed as

AdolescentAdultAntibodies, ViralChildChild, PreschoolChinaDried Blood Spot TestingFemaleHealth ResourcesHumansInfantInfant, NewbornMaleMeaslesMiddle AgedResearch DesignAntibodies, ViralChinaDisease eliminationDried blood spotsMeaslesSeroprevalence

Identifiers

PMID28965796
PMCPMC5874153
OpenAlexW2757494863

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.