Evidence map›Paper›PMID 28965747›Full record

ReviewTrends in biotechnology2017

Challenges of the Nano-Bio Interface in Lateral Flow and Dipstick Immunoassays.

Helena de Puig, Irene Bosch, Lee Gehrke, Kimberly Hamad-Schifferli

Abstract readReview
In one paragraph

Review in Trends in biotechnology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Rapid and Specific Detection ofACS applied bio materials · 2024
    Article
  8. Applications of Gold Nanoparticles in Plasmonic and Nanophotonic Biosensing.Advances in biochemical engineering/biotechnology · 2024
    Review
  9. Article
  10. Review
  11. Engineering Innovative Interfaces for Point-of-Care Diagnostics.Current opinion in colloid & interface science · 2023
    Review
  12. Biophysical and biochemical insights in the design of immunoassays.Biochimica et biophysica acta. General subjects · 2023
    Review
  13. Article
  14. Article
  15. Nanomaterial and interface advances in immunoassay biosensors.The journal of physical chemistry. C, Nanomaterials and interfaces · 2022
    Article
  16. Article
  17. Review
  18. Review
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Helena de PuigDepartment of Mechanical Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.
Irene BoschInstitute for Medical Engineering and Science, MIT, Cambridge, MA, USA.
Lee GehrkeInstitute for Medical Engineering and Science, MIT, Cambridge, MA, USA; Department of Microbiology and Immunology, Harvard Medical School, Boston, MA, USA.
Kimberly Hamad-SchifferliDepartment of Mechanical Engineering, Massachusetts Institute of Technology (MIT), Cambridge, MA, USA; Department of Engineering, University of Massachusetts Boston, Boston, MA, USA. Electronic address: kim.hamad@umb.edu.

Funding

MMDx: A rapid multiplexed matrix code diagnostic for real time epidemiologyR33AI100190 · NIAID · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GEHRKE, LEE · 2014 to 2016
$1.6M
MMDx: A rapid multiplexed matrix code diagnostic for real time epidemiologyR21AI100190 · NIAID · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI GEHRKE, LEE · 2012 to 2013
$436k
NIAID NIH HHS R21 AI100190NIAID NIH HHS R33 AI100190
6 · The paper itself

Abstract

Lateral flow assays (LFAs) are highly attractive for point-of-care (POC) diagnostics for infectious disease, food safety, and many other medical uses. The unique optical, electronic, and chemical properties that arise from the nanostructured and material characteristics of nanoparticles provide an opportunity to increase LFA sensitivity and impart novel capabilities. However, interfacing to nanomaterials in complex biological environments is challenging and can result in undesirable side effects such as non-specific adsorption, protein denaturation, and steric hindrance. These issues are even more acute in LFAs where there are many different types of inorganic-biological interfaces, often of a complex nature. Therefore, the unique properties of nanomaterials for LFAs must be exploited in a way that addresses these interface challenges.

Indexed as

AntibodiesAntigensBiosensing TechniquesEquipment DesignHumansImmunoassayNanoparticlesNanotechnologyQuantum DotsAntibodiesAntigensnano–bio interfacespaper-based assaysprotein coronasrapid diagnostics

Identifiers

PMID28965747
PMCPMC5696013

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.