Evidence map›Paper›PMID 28965701›Full record

ArticleNeurotoxicology2018

Environmental exposure to manganese in air: Tremor, motor and cognitive symptom profiles.

E S Kornblith, S L Casey, D T Lobdell, M A Colledge, R M Bowler

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurotoxicology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  19. Molecular Targets of Manganese-Induced Neurotoxicity: A Five-Year Update.International journal of molecular sciences · 2021
    Review
  20. Severity of parkinsonism associated with environmental manganese exposure.Environmental health : a global access science source · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

E S KornblithSan Francisco VA Medical Center, 4150 Clement Street, San Francisco, CA 94121, United States. Electronic address: Erica.Kornblith@va.gov.
S L CaseyAlliant International University, San Francisco, CA, United States.
D T LobdellUS EPA, Research Triangle Park, NC, United States.
M A ColledgeAgency for Toxic Substances and Disease Registry, Chicago, Il, United States.
R M BowlerSan Francisco State University, San Francisco, CA, United States.

Funding

Intramural CDC HHS CC999999Intramural EPA EPA999999
6 · The paper itself

Abstract

backgroundExcessive exposure to manganese (Mn) may cause parkinsonian-like motor and tremor symptoms and adverse cognitive effects, including problems with executive functioning (EF), resembling those found in later-stage Parkinson's disease (PD). Studies seeking to differentiate PD patients into subgroups with associated cognitive and functional outcomes using motor and tremor symptoms identified tremor-dominant (TD) and non-tremor dominant (NTD) subtypes. It is unclear whether differing patterns of pathophysiology and symptoms exist in Mn neurotoxicity, as they do in PD.

methodsResidents of East Liverpool (n=83) and Marietta, OH (n=99) exposed to chronic (>10years) environmental Mn through industrial pollution were administered neuropsychological measures and a physician-rated scale of movement-disorder symptoms. Two-step cluster analysis was used to group residents based on tremor symptoms, bradykinesia/rigidity symptoms, gait disturbance, and executive function. Cluster membership was validated using modeled air-Mn exposure and a computerized tremor measure.

resultsElevated tremor and motor symptoms and executive dysfunction were observed, and TD and NTD symptom clusters were identified. Two additional clusters were also identified: Executive Dysfunction and Normal Functioning. The NTD residents, with elevated levels of gait disturbance and other movement disorder symptoms, did not evidence EF impairment, as predicted. Instead, residents with EF impairment formed their own cluster, and were relatively free of movement disorder symptoms.

conclusionsResults resemble reports in the PD literature with TD and NTD clusters identified, but executive dysfunction did not cluster with NTD symptoms. PD and Mn exposure likely have differing pathophysiology and developmental courses, and therefore different symptom patterns, even when similar symptoms are present.

Indexed as

Environmental ExposureAgedAir PollutantsCognitive DysfunctionFemaleGait Disorders, NeurologicHumansHypokinesiaMaleManganeseNeuropsychological TestsOhioParkinson Disease, SecondaryTremorAir PollutantsManganeseExecutive functionManganeseNeurotoxicologyTremor

Identifiers

PMID28965701
PMCPMC6260785

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.