Evidence map›Paper›PMID 28965641›Full record

ReviewImmunology and allergy clinics of North America2017

Severe Delayed Drug Reactions: Role of Genetics and Viral Infections.

Rebecca Pavlos, Katie D White, Celestine Wanjalla, Simon A Mallal, Elizabeth J Phillips

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Immunology and allergy clinics of North America, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
  13. Review
  14. Delabeling Delayed Drug Hypersensitivity: How Far Can You Safely Go?The journal of allergy and clinical immunology. In practice · 2020
    Article
  15. Hypersensitivity Reactions: An Everyday Occurrence in Pediatric Allergy Clinics.Pediatric allergy, immunology, and pulmonology · 2020
    Review
  16. [Three keys to the appropriate choice of oral antibiotic treatment in the respiratory tract infections].Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia · 2019
    Review
  17. Review
  18. Adaptive immune cells in calcific aortic valve disease.American journal of physiology. Heart and circulatory physiology · 2019
    Review
  19. Review
  20. Antibiotic allergy.Lancet (London, England) · 2019
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Rebecca PavlosInstitute for Immunology and Infectious Diseases, Murdoch University, 6150 Murdoch, Western Australia, Australia.
Katie D WhiteDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Celestine WanjallaDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Simon A MallalInstitute for Immunology and Infectious Diseases, Murdoch University, 6150 Murdoch, Western Australia, Australia; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA.
Elizabeth J PhillipsInstitute for Immunology and Infectious Diseases, Murdoch University, 6150 Murdoch, Western Australia, Australia; Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, TN, USA; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN, USA. Electronic address: elizabeth.j.phillips@vanderbilt.edu.

Funding

Understanding and preventing HLA-associated drug reactionsP50GM115305 · NIGMS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PHILLIPS, ELIZABETH · 2015 to 2019
$13.0M
NIGMS NIH HHS P50 GM115305
6 · The paper itself

Abstract

Adverse drug reactions (ADRs) are a significant source of patient morbidity and mortality and represent a major burden to health care systems and drug development. Up to 50% of such reactions are preventable. Although many ADRs can be predicted based on the on-target pharmacologic activity, ADRs arising from drug interactions with off-target receptors are recognized. Off-target ADRs include the immune-mediated ADRs (IM-ADRs) and pharmacologic drug effects. In this review, we discuss what is known about the immunogenetics and pathogenesis of IM-ADRs and the hypothesized role of heterologous immunity in the development of IM-ADRs.

Indexed as

Antigens, ViralAutoantigensCross ReactionsDrug-Related Side Effects and Adverse ReactionsGene FrequencyGenetic Predisposition to DiseaseGenotypeHLA AntigensHumansImmunologic MemoryPolymorphism, GeneticRiskT-LymphocytesVirus DiseasesAntigens, ViralAutoantigensHLA AntigensAdverse drug reactionDrug reaction with eosinophilia and systemic symptomsHuman herpes virusHuman leukocyte antigenPharmacogenomicsSteven Johnson syndromeT-cell receptorToxic epidermal necrolysis

Identifiers

PMID28965641
PMCPMC5702581

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.