Evidence map›Paper›PMID 28965516›Full record

ArticleEpidemiology and infection2017

High prevalence of Seoul hantavirus in a breeding colony of pet rats.

L M McELHINNEY, D A Marston, K C Pounder, H Goharriz, E L Wise, J Verner-Carlsson, D Jennings, N Johnson, A Civello, A Nunez and 6 more

Open access · hybridAbstract read
In one paragraph

Article in Epidemiology and infection, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 31 citations in OpenAlex.

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  9. ZoonoticViruses · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 4 countries.

L M McELHINNEYDepartment of Virology,Animal and Plant Health Agency (APHA),Weybridge,Surrey,UK.ORCID 0000-0002-6022-348X
D A MarstonDepartment of Virology,Animal and Plant Health Agency (APHA),Weybridge,Surrey,UK.
K C PounderHPRU Emerging and Zoonotic Infections,Institute of Infection and Global Health,University of Liverpool,Liverpool,UK.
H GoharrizDepartment of Virology,Animal and Plant Health Agency (APHA),Weybridge,Surrey,UK.
E L WiseDepartment of Virology,Animal and Plant Health Agency (APHA),Weybridge,Surrey,UK.
J Verner-CarlssonDepartment of Medical Biochemistry and Microbiology and Department of Medical Sciences,Zoonosis Science Centre,Uppsala University,Uppsala,Sweden.
D JenningsDepartment of Virology,Animal and Plant Health Agency (APHA),Weybridge,Surrey,UK.
N JohnsonDepartment of Virology,Animal and Plant Health Agency (APHA),Weybridge,Surrey,UK.
A CivelloDepartment of Pathology,APHA,Weybridge,Surrey,UK.
A NunezDepartment of Pathology,APHA,Weybridge,Surrey,UK.
T BrooksHPRU Emerging and Zoonotic Infections,Institute of Infection and Global Health,University of Liverpool,Liverpool,UK.
A C BreedDepartment of Epidemiological Sciences,APHA,Weybridge,Surrey,UK.
J LawesDepartment of Epidemiological Sciences,APHA,Weybridge,Surrey,UK.
Å LundkvistDepartment of Medical Biochemistry and Microbiology and Department of Medical Sciences,Zoonosis Science Centre,Uppsala University,Uppsala,Sweden.
C A FeatherstoneAPHA,Thirsk Veterinary Investigation Centre,Thirsk,UK.
A R FooksDepartment of Virology,Animal and Plant Health Agency (APHA),Weybridge,Surrey,UK.
Animal and Plant Health Agency · GBUniversity of Liverpool · GBUppsala University · SEWeybridge Community Hospital · GBThird Way · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

As part of further investigations into three linked haemorrhagic fever with renal syndrome (HFRS) cases in Wales and England, 21 rats from a breeding colony in Cherwell, and three rats from a household in Cheltenham were screened for hantavirus. Hantavirus RNA was detected in either the lungs and/or kidney of 17/21 (81%) of the Cherwell rats tested, higher than previously detected by blood testing alone (7/21, 33%), and in the kidneys of all three Cheltenham rats. The partial L gene sequences obtained from 10 of the Cherwell rats and the three Cheltenham rats were identical to each other and the previously reported UK Cherwell strain. Seoul hantavirus (SEOV) RNA was detected in the heart, kidney, lung, salivary gland and spleen (but not in the liver) of an individual rat from the Cherwell colony suspected of being the source of SEOV. Serum from 20/20 of the Cherwell rats and two associated HFRS cases had high levels of SEOV-specific antibodies (by virus neutralisation). The high prevalence of SEOV in both sites and the moderately severe disease in the pet rat owners suggest that SEOV in pet rats poses a greater public health risk than previously considered.

Indexed as

OrthohantavirusAdultAnimalsEnglandFemaleHemorrhagic Fever with Renal SyndromeHumansKidneyLungMalePhylogenyPrevalenceRatsWalesHantavirusRabies (animal)Rabies (human)Virology (human) and epidemiologyZoonoses

Identifiers

PMID28965516
PMCPMC9148732
OpenAlexW2764181079

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.