Evidence map›Paper›PMID 28965513›Full record

ReviewVisual neuroscience2017

An evolving view of retinogeniculate transmission.

Elizabeth Y Litvina, Chinfei Chen

Open access · bronzeAbstract readReview
In one paragraph

Review in Visual neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 23 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Elizabeth Y LitvinaDepartment of Neurology,F.M. Kirby Neurobiology Center,Children's Hospital, Boston,Boston,Massachusetts 02115.
Chinfei ChenDepartment of Neurology,F.M. Kirby Neurobiology Center,Children's Hospital, Boston,Boston,Massachusetts 02115.ORCID 0000-0002-6486-3097
Boston Children's Hospital · US

Funding

Short-term plasticity of the retinogeniculate synapseR01EY013613 · NEI · CHILDREN'S HOSPITAL BOSTON · PI Chinfei Chen · 2003 to 2026
$10.3M
Mouse Neurodevelopmental Behavior CoreU54HD090255 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI POMEROY, SCOTT LOREN · 2016 to 2020
$5.2M
NEI NIH HHS R01 EY013613NICHD NIH HHS U54 HD090255
6 · The paper itself

Abstract

The thalamocortical (TC) relay neuron of the dorsoLateral Geniculate Nucleus (dLGN) has borne its imprecise label for many decades in spite of strong evidence that its role in visual processing transcends the implied simplicity of the term "relay". The retinogeniculate synapse is the site of communication between a retinal ganglion cell and a TC neuron of the dLGN. Activation of retinal fibers in the optic tract causes reliable, rapid, and robust postsynaptic potentials that drive postsynaptics spikes in a TC neuron. Cortical and subcortical modulatory systems have been known for decades to regulate retinogeniculate transmission. The dynamic properties that the retinogeniculate synapse itself exhibits during and after developmental refinement further enrich the role of the dLGN in the transmission of the retinal signal. Here we consider the structural and functional substrates for retinogeniculate synaptic transmission and plasticity, and reflect on how the complexity of the retinogeniculate synapse imparts a novel dynamic and influential capacity to subcortical processing of visual information.

Indexed as

AnimalsExcitatory Postsynaptic PotentialsGeniculate BodiesPatch-Clamp TechniquesRetinal Ganglion CellsSynapsesSynaptic TransmissionVisual PathwaysDevelopmental refinementRetinogeniculate synapseShort-term plasticitySynaptic transmissionVisual circuit

Identifiers

PMID28965513
PMCPMC6180333
OpenAlexW2752907696

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.