Evidence map›Paper›PMID 28965351›Full record

ArticleCancer medicine2017

Identification of keratin 19-positive cancer stem cells associating human hepatocellular carcinoma using CYFRA 21-1.

Takayuki Kawai, Kentaro Yasuchika, Takamichi Ishii, Hokahiro Katayama, Elena Yukie Yoshitoshi, Satoshi Ogiso, Takahito Minami, Yuya Miyauchi, Hidenobu Kojima, Ryoya Yamaoka and 6 more

Open access · goldAbstract read
In one paragraph

Article in Cancer medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
0.9field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Keratin 17 Promotes Lung Adenocarcinoma Progression by Enhancing Cell Proliferation and Invasion.Medical science monitor : international medical journal of experimental and clinical research · 2018
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 1 institution in 2 countries.

Takayuki KawaiDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.ORCID http://orcid.org/0000-0001-7520-6861
Kentaro YasuchikaDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Takamichi IshiiDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Hokahiro KatayamaDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Elena Yukie YoshitoshiDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Satoshi OgisoDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Takahito MinamiDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Yuya MiyauchiDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Hidenobu KojimaDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Ryoya YamaokaDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Sadahiko KitaDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Katsutaro YasudaDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Naoya SasakiDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Ken FukumitsuDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Etsuro HatanoDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Shinji UemotoDepartment of Surgery, Graduate School of Medicine, Kyoto University, Kyoto, Japan.
Kyoto University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The current lack of an easily measurable surrogate marker of cancer stem cells (CSCs) prevents the clinical application of CSCs for hepatocellular carcinoma (HCC). We previously reported that keratin 19 (K19) is a novel HCC-CSC marker associated with transforming growth factor beta (TGFβ)/Smad signaling, and that K19

Indexed as

Antigens, NeoplasmBiomarkers, TumorCarcinoma, HepatocellularCell Line, TumorDisease-Free SurvivalGene ExpressionGene SilencingHumansKeratin-19Liver NeoplasmsNeoplasm GradingNeoplasm InvasivenessNeoplasms, Multiple PrimaryNeoplastic Stem CellsPromoter Regions, GeneticProtein Kinase Inhibitorsantigen CYFRA21.1Antigens, NeoplasmBiomarkers, TumorKeratin-19LY-2157299Protein Kinase InhibitorsPyrazolesQuinolinesReceptors, Transforming Growth Factor betacancer stem cellsCYFRA 21-1hepatocellular carcinomakeratin 19transforming growth factor beta receptor 1 inhibitor

Identifiers

PMID28965351
PMCPMC5673926
OpenAlexW2758791758

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.