ArticleClinical research in cardiology : official journal of the German Cardiac Society2018
The T-peak-to-T-end interval: a novel ECG marker for ventricular arrhythmia and appropriate ICD therapy in patients with hypertrophic cardiomyopathy.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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14 citing papers in PubMed, 19 citations in OpenAlex.
- Exploring the association of electrocardiographic markers and arrhythmic risk in hypertrophic cardiomyopathy: A systematic review and meta-analysis.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2026Review
- Ventricular dispersion and repolarization in Marfan syndrome: A clinical analysis.Heart rhythm O2 · 2025Article
- Predictive Value of Electrocardiographic Markers Versus Echocardiographic and Clinical Measures for Appropriate ICD Shocks in Heart Failure Patients.Journal of clinical medicine · 2025Article
- Nicorandil as a promising therapeutic option for ventricular arrhythmia: A case report and review of literature.World journal of cardiology · 2024Article
- Current perspectives of sudden cardiac death management in hypertrophic cardiomyopathy.Heart failure reviews · 2024Review
- Reply to the Editor: Inquiries about Tpe and ventricular arrhythmias in patients with takotsubo syndrome.Heart rhythm O2 · 2024Article
- Tpeak-Tend ECG Marker in Obesity and Cardiovascular Diseases: A Comprehensive Review.Scientifica · 2024Review
- TVeterinary research communications · 2023Article
- Ventricular Repolarization Dispersion is a Potential Risk for the Development of Life-Threatening Arrhythmia in Children with Hypertrophic Cardiomyopathy.Pediatric cardiology · 2022Article
- Prognostic Effect of Underlying Chronic Kidney Disease and Renal Replacement Therapy on the Outcome of Patients after Out-of-Hospital Cardiac Arrest: A Nationwide Observational Study.Medicina (Kaunas, Lithuania) · 2022Observational
- Common Genetic Variants Modulate the Electrocardiographic Tpeak-to-Tend Interval.American journal of human genetics · 2020Article
- Prognostic impact of recurrences of ventricular tachyarrhythmias and appropriate ICD therapies in a high-risk ICD population.Clinical research in cardiology : official journal of the German Cardiac Society · 2019Article
- Prognostic impact of chronic kidney disease and renal replacement therapy in ventricular tachyarrhythmias and aborted cardiac arrest.Clinical research in cardiology : official journal of the German Cardiac Society · 2019Observational
- Genetic basis of hypertrophic cardiomyopathy in children.Clinical research in cardiology : official journal of the German Cardiac Society · 2019Article
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7 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
introductionHypertrophic cardiomyopathy (HCM) is associated with an increased risk of sudden cardiac death (SCD) primarily due to ventricular arrhythmia (VA). In patients (pts.) with a high risk of SCD, the implantation of an intracardiac cardioverter defibrillator (ICD) is thus indicated. Previous studies suggest that a prolonged interval between the peak and the end of the T wave, T-peak to T-end (TpTe), is associated with an elevated risk of VA and SCD in various clinical settings. The aim of our study was to evaluate the association between TpTe and VA in HCM pts. with a previously implanted ICD.
methodsIn 40 HCM pts. (51.4 ± 16.4 years; 62.5% men), TpTe was measured using the baseline digital standard resting 12-lead ECG during sinus rhythm. VA was assessed by device follow-up.
resultsWithin 41.8 ± 35.1 months, 7 (17.5%) pts. had VA leading to appropriate therapy (AT), 7 pts. (17.5%) had non-sustained VA, and 26 pts. (65.0%) had no VA. The maximum TpTe was significantly prolonged in pts. with VA leading to AT compared to pts. without VA (101.3 ± 19.6 vs. 79.9 ± 15.3 ms; p = 0.004). Maximum TpTe was associated with an elevated risk of VA leading to AT (hazard ratio per 10 ms increase 1.63; 95% CI 1.04-2.54; p = 0.031) and pts. with a maximum TpTe ≤ 78 ms were without any VA leading to AT during follow-up. There was no correlation of maximum TpTe to other clinical parameters in our patient cohort.
conclusionA prolonged TpTe is associated with VA and AT in HCM. Our findings suggest that TpTe can possibly serve as a marker for ventricular arrhythmogenesis in pts. with HCM and assessment of TpTe might, therefore, optimize SCD risk stratification.
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