ArticleLipids2017
Lipid Metabolism is Closely Associated with Normal Testicular Growth Based on Global Transcriptome Profiles in Normal and Underdeveloped Testis of Obese Zucker (fa/fa) Rats.
Article in Lipids, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Quantification of testicular fat content: the value of evaluating testicular function after cryptorchidism surgery.Pediatric research · 2024Article
- Age-dependent changes in the expression and localization of LYZL4, LYZL6 and PCNA during testicular development in the Ashidan yak.Animal biotechnology · 2024Article
- Male infertility risk and plasma lipidome: a Mendelian randomization study.Frontiers in endocrinology · 2024Article
- Characterization of the structural, oxidative, and immunological features of testis tissue from Zucker diabetic fatty rats.Open life sciences · 2022Article
- Proteomics analysis reveals the effect of 1α,25(OH)Scientific reports · 2021Article
- Histological Analysis, Bioinformatics Profile, and Expression of Methylenetetrahydrofolate Reductase (MTHFR) in Bovine Testes.Animals : an open access journal from MDPI · 2020Article
- Quantification of testicular fat deposition in the evaluation of middle-aged overweight male infertility.Magma (New York, N.Y.) · 2020Article
- Validation of Suitable Reference Genes for Gene Expression Studies on Yak Testis Development.Animals : an open access journal from MDPI · 2020Article
- Interpretation of Fiber Supplementation on Offspring Testicular Development in a Pregnant Sow Model from a Proteomics Perspective.International journal of molecular sciences · 2019Article
- Expression of Hypoxia-Inducible Factor 1α (HIF-1α) and Genes of Related Pathways in Altered Gravity.International journal of molecular sciences · 2019Article
- High fat diet induced obesity is mitigated in Cyp3a-null female mice.Chemico-biological interactions · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Zucker (fa/fa) obese rats often have non-identical and differently sized paired testes, leaving one testis underdeveloped. Our earlier study found that the underdeveloped testes, > 30% smaller than the normal ones, have a selective decrease in docosapentaenoic acid (22:5n-6), a dominant fatty acid in the testes. This study was conducted to examine global testicular transcriptome profile in underdeveloped testes relative to developed ones using Rat Gene 2.0 ST Array (Affymetrix, USA). Testes were obtained from 14-week-old, sexually mature male obese (fa/fa) Zucker rats. Out of the 1790 transcripts differentially expressed, 1108 and 682 were over-expressed in the underdeveloped and normal testis, respectively (fold change ≥ 2 and P < 0.05). The ingenuity pathway analysis indicated that transcripts that were under-expressed in the underdeveloped testis, relative to the normal testes, are involved in triacylglycerol biosynthesis, sphingomyelin metabolism and phosphatidylglycerol biosynthesis. Transcripts that were over-expressed in underdeveloped testes, relative to normal testis, are involved in the production of nitric oxide and reactive oxygen species, and nuclear factor (erythroid-derived 2)-like 2 mediated oxidative stress responses. These data indicate that genes involved in lipid metabolism and oxidative stress play a crucial role in testicular growth and the maintenance of testical health.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.