ArticleClinical oral investigations2018
Doxycycline-loaded nanotube-modified adhesives inhibit MMP in a dose-dependent fashion.
Article in Clinical oral investigations, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.
- Exploring the effectiveness of doxycycline in restorative dentistry: a systematic review of in vitro studies.Odontology · 2025Pooled it
- Characterizing Curing Efficiency of EGCG-Encapsulated Halloysite Nanotube Modified Adhesives for Durable Dentin-Resin Interfaces.Polymers · 2024Article
- Release and MMP-9 Inhibition Assessment of Dental Adhesive Modified with EGCG-Encapsulated Halloysite Nanotubes.Nanomaterials (Basel, Switzerland) · 2023Article
- The Allogenic Dental Pulp Transplantation from Son/Daughter to Mother/Father: A Follow-Up of Three Clinical Cases.Bioengineering (Basel, Switzerland) · 2022Article
- Current Strategies to Control Recurrent and Residual Caries with Resin Composite Restorations: Operator- and Material-Related Factors.Journal of clinical medicine · 2022Review
- Physicochemical and microbiological assessment of a dental adhesive doped with cashew nut shell liquid.Odontology · 2022Article
- Metal Oxide Nanoparticles and Nanotubes: Ultrasmall Nanostructures to Engineer Antibacterial and Improved Dental Adhesives and Composites.Bioengineering (Basel, Switzerland) · 2021Review
- Bibliometric Analysis of Literature Published on Antibacterial Dental Adhesive from 1996-2020.Polymers · 2020Review
- Injectable MMP-Responsive Nanotube-Modified Gelatin Hydrogel for Dental Infection Ablation.ACS applied materials & interfaces · 2020Article
- The anti-neoplastic effect of doxycycline in osteosarcoma as a metalloproteinase (MMP) inhibitor: a systematic review.Clinical sarcoma research · 2020Review
- Physicochemical and biological properties of novel chlorhexidine-loaded nanotube-modified dentin adhesive.Journal of biomedical materials research. Part B, Applied biomaterials · 2019Article
- Interaction of Selected Terpenoids FromBioinformatics and biology insights · 2019Article
- Doxycycline Attenuates Atrial Remodeling by Interfering with MicroRNA-21 and Downstream Phosphatase and Tensin Homolog (PTEN)/Phosphoinositide 3-Kinase (PI3K) Signaling Pathway.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Physicochemical and Microbiological Assessment of an Experimental Composite Doped with Triclosan-Loaded Halloysite Nanotubes.Materials (Basel, Switzerland) · 2018Article
- Modified Polymeric Nanoparticles Exert In Vitro Antimicrobial Activity Against Oral Bacteria.Materials (Basel, Switzerland) · 2018Article
Corrections and comments
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Authors and funding
6 authors at 5 institutions in 2 countries.
Funding
Abstract
objectivesThis article evaluated the drug loading, release kinetics, and matrix metalloproteinase (MMP) inhibition of doxycycline (DOX) released from DOX-loaded nanotube-modified adhesives. DOX was chosen as the model drug, since it is the only MMP inhibitor approved by the U.S. Food and Drug Administration. MATERIALS AND
methodsDrug loading into the nanotubes was accomplished using DOX solution at distinct concentrations. Increased concentrations of DOX significantly improved the amount of loaded DOX. The modified adhesives were fabricated by incorporating DOX-loaded nanotubes into the adhesive resin of a commercial product. The degree of conversion (DC), Knoop microhardness, DOX release kinetics, antimicrobial, cytocompatibility, and anti-MMP activity of the modified adhesives were investigated.
resultsIncorporation of DOX-loaded nanotubes did not compromise DC, Knoop microhardness, or cell compatibility. Higher concentrations of DOX led to an increase in DOX release in a concentration-dependent manner from the modified adhesives. DOX released from the modified adhesives did not inhibit the growth of caries-related bacteria, but more importantly, it did inhibit MMP-1 activity.
conclusionsThe loading of DOX into the nanotube-modified adhesives did not compromise the physicochemical properties of the adhesives and the released levels of DOX were able to inhibit MMP activity without cytotoxicity. CLINICAL SIGNIFICANCE: Doxycycline released from the nanotube-modified adhesives inhibited MMP activity in a concentration-dependent fashion. Therefore, the proposed nanotube-modified adhesive may hold clinical potential as a strategy to preserve resin/dentin bond stability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.