Evidence map›Paper›PMID 28965218›Full record

ArticleNeurotoxicity research2018

Upregulation of Vesicular Glutamate Transporter 2 and STAT3 Activation in the Spinal Cord of Mice Receiving 3,3'-Iminodipropionitrile.

Tomohiro Ohgomori, Ryo Yamasaki, Jun-Ichi Kira, Shozo Jinno

Abstract read
PubMed Publisher
In one paragraph

Article in Neurotoxicity research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Alterations in Leptin Signaling in Amyotrophic Lateral Sclerosis (ALS).International journal of molecular sciences · 2021
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Tomohiro OhgomoriDepartment of Anatomy and Neuroscience, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.
Ryo YamasakiDepartment of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.
Jun-Ichi KiraDepartment of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, 812-8582, Japan.
Shozo JinnoDepartment of Anatomy and Neuroscience, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan. sjnno@med.kyushu-u.ac.jp.ORCID 0000-0002-7596-8118
Kyushu University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic administration of 3,3'-iminodipropionitrile (IDPN) causes axonal impairment. Although controversy still remains, it has been suggested that IDPN intoxication mimics the axonopathy of amyotrophic lateral sclerosis (ALS). Interestingly, recent studies including our own showed that signal transducer and activator of transcription 3 (STAT3) in spinal α-motoneurons was activated in both IDPN-treated mice and SOD1

Indexed as

AnimalsBenzoxazolesCholine O-AcetyltransferaseExcitatory Amino Acid Transporter 2MaleMiceMice, Inbred C57BLMice, TransgenicMotor NeuronsNerve Tissue ProteinsNitrilesPresynaptic TerminalsQuinolinium CompoundsSpinal CordSpinal Nerve RootsSTAT3 Transcription Factor1,1'-((4,4,7,7-tetramethyl)-4,7-diazaundecamethylene)bis-4-(3-methyl-2,3-dihydro(benzo-1,3-oxazole)-2-methylidene)quinolinium3,3'-iminodipropionitrileBenzoxazolesCholine O-AcetyltransferaseExcitatory Amino Acid Transporter 2Nerve Tissue ProteinsNitrilesQuinolinium CompoundsSOD1 G93A proteinSTAT3 Transcription FactorSuperoxide DismutaseSynaptophysinVesicular Glutamate Transport Protein 23,3′-IminodipropionitrileAmyotrophic lateral sclerosisSignal transducer and activator of transcription 3SOD1 G93A mouseVesicular glutamate transporter 2

Identifiers

PMID28965218
OpenAlexW2760178122

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.