Evidence map›Paper›PMID 28965162›Full record

ArticleJournal of neuro-oncology2018

Germline polymorphisms in myeloid-associated genes are not associated with survival in glioma patients.

Daniel I Jacobs, Yanhong Liu, Konrad Gabrusiewicz, Spiridon Tsavachidis, Georgina N Armstrong, Renke Zhou, Jun Wei, Cristina Ivan, George Calin, Annette M Molinaro and 7 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuro-oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 3 institutions in 1 country.

Daniel I JacobsDepartment of Medicine, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, One Baylor Plaza, Mailstop BCM305, Houston, TX, 77030, USA.ORCID http://orcid.org/0000-0002-8738-3184
Yanhong LiuDepartment of Medicine, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, One Baylor Plaza, Mailstop BCM305, Houston, TX, 77030, USA.
Konrad GabrusiewiczDepartment of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Spiridon TsavachidisDepartment of Medicine, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, One Baylor Plaza, Mailstop BCM305, Houston, TX, 77030, USA.
Georgina N ArmstrongDepartment of Medicine, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, One Baylor Plaza, Mailstop BCM305, Houston, TX, 77030, USA.
Renke ZhouDepartment of Medicine, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, One Baylor Plaza, Mailstop BCM305, Houston, TX, 77030, USA.
Jun WeiDepartment of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA.
Cristina IvanDepartment of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
George CalinDepartment of Experimental Therapeutics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Annette M MolinaroDepartment of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA.
Terri RiceDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Paige M BracciDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Helen M HansenDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
John K WienckeDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Margaret R WrenschDepartment of Neurological Surgery, University of California, San Francisco, San Francisco, CA, USA.
Amy B HeimbergerDepartment of Neurosurgery, The University of Texas MD Anderson Cancer Center, Houston, TX, 77030, USA. aheimber@mdanderson.org.
Melissa L BondyDepartment of Medicine, Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, One Baylor Plaza, Mailstop BCM305, Houston, TX, 77030, USA. mbondy@bcm.edu.ORCID http://orcid.org/0000-0002-0278-414X
Baylor College of Medicine · USUniversity of California, San Francisco · USThe University of Texas MD Anderson Cancer Center · US

Funding

UCSF CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR024131 · NCRR · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI JOHNSTON, S. CLAIBORNE · 2006 to 2011
$111.2M
Tissue CoreP50CA097257 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joseph F Costello · 2002 to 2026
$57.4M
Tropism Enhanced Oncolytic Adenovirus for the Treatment of Brain TumorsP50CA127001 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Juan Fueyo · 2008 to 2026
$41.2M
CALIFORNIA COORDINATED CANCER PREVENTION & CONTROL PROGRAMU58DP003862 · DP · CALIFORNIA STATE DEPT OF PUBLIC HEALTH · PI SNIPES, KURT P · 2012 to 2014
$31.5M
GENETIC EPIDEMIOLOGY OF MALIGNANT GLIOMAR01CA052689 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WIENCKE, JOHN K., WRENSCH, MARGARET R. · 1991 to 2015
$20.5M
International Case Control Study of Malignant GliomaR01CA139020 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BONDY, MELISSA L. · 2010 to 2015
$16.0M
Genetic Epidemiology of Glioma International ConsortiumR01CA119215 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI BONDY, MELISSA L. · 2006 to 2010
$11.9M
Modulation of Microglia and T Cell Interactions in Malignant GliomaR01CA120813 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI HEIMBERGER, AMY BETH, RAO, GANESH · 2007 to 2025
$4.7M
Immune epigenetic biomarkers of survival in glioma epidemiologyR01CA207360 · NCI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI WIENCKE, JOHN K. · 2017 to 2021
$3.8M
MOLECULAR EPIDEMIOLOGY OF GLIOMASR01CA070917 · NCI · UNIVERSITY OF TEXAS MD ANDERSON CAN CTR · PI BONDY, MELISSA L · 1996 to 2004
$3.0M
Lung Cancer Prediction Models Incorporating Exome Data from Extreme PhenotypesK07CA181480 · NCI · BAYLOR COLLEGE OF MEDICINE · PI LIU, YANHONG · 2014 to 2017
$511k
NCCDPHP CDC HHS U58 DP003862NCI NIH HHS HHSN261201000034CNCI NIH HHS HHSN261201000035CNCI NIH HHS HHSN261201000035INCI NIH HHS HHSN261201000140CNCI NIH HHS K07 CA181480NCI NIH HHS P50 CA097257NCI NIH HHS P50 CA127001NCI NIH HHS R01 CA052689NCI NIH HHS R01 CA070917NCI NIH HHS R01 CA119215NCI NIH HHS R01 CA120813NCI NIH HHS R01 CA139020NCI NIH HHS R01 CA207360NCRR NIH HHS UL1 RR024131NIH HHS K07 CA181480NIH HHS P50CA097257NIH HHS P50 CA127001NIH HHS R01 CA070917NIH HHS R01 CA119215NIH HHS R01 CA120813NIH HHS R01 CA139020NIH HHS R01CA139020NIH HHS R01CA52689
6 · The paper itself

Abstract

Immune cells of myeloid origin, including microglia, macrophages, and myeloid-derived suppressor cells adopt immunosuppressive phenotypes that support gliomagenesis. Here, we tested an a priori hypothesis that single nucleotide polymorphisms (SNPs) in genes related to glioma-associated myeloid cell regulation and function are also associated with patient survival after glioma diagnosis. Subjects for this study were 992 glioma patients treated at The University of Texas MD Anderson Cancer Center in Houston, Texas between 1992 and 2008. Haplotype-tagging SNPs in 91 myeloid-associated genes were analyzed for association with survival by Cox regression. Individual SNP- and gene-based tests were performed separately in glioblastoma (WHO grade IV, n = 511) and lower-grade glioma (WHO grade II-III, n = 481) groups. After adjustment for multiple testing, no myeloid-associated gene variants were significantly associated with survival in glioblastoma. Two SNPs, rs147960238 in CD163 (p = 2.2 × 10

Indexed as

AdolescentAdultAgedBrain NeoplasmsFemaleGenetic Predisposition to DiseaseGenotypeGlioblastomaHumansMaleMiddle AgedMyeloid CellsPolymorphism, Single NucleotideYoung AdultGenetic polymorphismGlioblastomaGliomaGlioma-associated myeloid cellsImmune suppressionSurvival

Identifiers

PMID28965162
PMCPMC5756111
OpenAlexW2759031874

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.