ArticleAntonie van Leeuwenhoek2018
The FlbA-regulated predicted transcription factor Fum21 of Aspergillus niger is involved in fumonisin production.
Article in Antonie van Leeuwenhoek, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 32 citations in OpenAlex.
- Unveiling the new chapter in nanobody engineering: advances in traditional construction and AI-driven optimization.Journal of nanobiotechnology · 2025Review
- The palmitoyl-CoA ligase Fum16 is part of amBio · 2025Article
- Global regulation of fungal secondary metabolism inEngineering microbiology · 2023Article
- Rgs1 is a regulator of effector gene expression during plant infection by the rice blast fungusProceedings of the National Academy of Sciences of the United States of America · 2023Article
- Genetic Regulation of Mycotoxin Biosynthesis.Journal of fungi (Basel, Switzerland) · 2022Review
- Fumonisins in African Countries.Toxins · 2022Review
- Advances in space microbiology.iScience · 2021Review
- Two regulators of G-protein signaling (RGS) proteins FlbA1 and FlbA2 differentially regulate fumonisin B1 biosynthesis in Fusarium verticillioides.Current genetics · 2021Article
- Metabolomic Analysis ofFrontiers in microbiology · 2020Article
- Construction of a Codon-Adapted Nourseotricin-Resistance Marker Gene for Efficient Targeted Gene Deletion in the Mycophenolic Acid ProducerJournal of fungi (Basel, Switzerland) · 2019Article
- Involvement of a G Protein Regulatory Circuit in Alternative Oxidase Production inG3 (Bethesda, Md.) · 2019Article
- Harnessing the knowledge of protein secretion for enhanced protein production in filamentous fungi.World journal of microbiology & biotechnology · 2019Review
- FlbA-Regulated GeneApplied and environmental microbiology · 2019Article
- Constitutive hyperproduction of sorbicillinoids inBiotechnology for biofuels · 2018Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Aspergillus niger secretes proteins throughout the colony except for the zone that forms asexual spores called conidia. Inactivation of flbA that encodes a regulator of G-protein signaling results in colonies that are unable to reproduce asexually and that secrete proteins throughout the mycelium. In addition, the ΔflbA strain shows cell lysis and has thinner cell walls. Expression analysis showed that 38 predicted transcription factor genes are differentially expressed in strain ΔflbA. Here, the most down-regulated predicted transcription factor gene, called fum21, was inactivated. Growth, conidiation, and protein secretion were not affected in strain Δfum21. Whole genome expression analysis revealed that 63 and 11 genes were down- and up-regulated in Δfum21, respectively, when compared to the wild-type strain. Notably, 24 genes predicted to be involved in secondary metabolism were down-regulated in Δfum21, including 10 out of 12 genes of the fumonisin cluster. This was accompanied by absence of fumonisin production in the deletion strain and a 25% reduction in production of pyranonigrin A. Together, these results link FlbA-mediated sporulation-inhibited secretion with mycotoxin production.
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