Evidence map›Paper›PMID 28965106›Full record

Trial reportJournal of neurointerventional surgery2018

Safety and efficacy of aneurysm treatment with WEB in the cumulative population of three prospective, multicenter series.

Laurent Pierot, Jacques Moret, Xavier Barreau, Istvan Szikora, Denis Herbreteau, Francis Turjman, Markus Holtmannspötter, Anne-Christine Januel, Vincent Costalat, Jens Fiehler and 11 more

Registry-linked trialOpen access · hybridAbstract readClinical TrialMulticenter Study
In one paragraph

Trial report in Journal of neurointerventional surgery, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01778322 (WEB Clinical Assessment of IntraSaccular Aneurysm Therapy), which is not on this map. Cited by 99 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
99citing papers in PubMed, 7 pooled it
15.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01778322 completednot on this map

WEB Clinical Assessment of IntraSaccular Aneurysm Therapy

TypeobservationalSponsorMicrovention-Terumo, Inc.Ran2011 to 2019Enrolled51ConditionsIntracranial AneurysmArmsIntracranial aneurysm embolization
3 · Its place in the literature

Who cites it

99 citing papers in PubMed, 7 syntheses or guidelines pooled it, 200 citations in OpenAlex.

  1. The Woven EndoBridge device, an effective and safe alternative endovascular treatment of intracranial aneurysm-systematic review.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2026
    Pooled it
  2. Pooled it
  3. Pooled it
  4. Endoluminal flow diverters in the treatment of sidewall and bifurcation aneurysm: A systematic review and meta-analysis of complications and angiographic outcomes.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2022
    Pooled it
  5. Pooled it
  6. Pooled it
  7. A systematic review and meta-analysis of Woven EndoBridge single layer for treatment of intracranial aneurysms.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2020
    Pooled it
  8. Trial
  9. Trial
  10. The RISE trial: A Randomized Trial on Intra-Saccular Endobridge devices.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2020
    Trial
  11. Trial
  12. Trial
  13. Observational
  14. Article
  15. A case report and literature review of multiple complications in the treatment of an aneurysm with the woven endobridge device.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

39 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 19 institutions in 6 countries.

Laurent PierotHôpital Maison-Blanche, Université Reims-Champagne-Ardenne, Reims, France.
Jacques MoretHôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, Kremlin-Bicêtre, France.
Xavier BarreauCHU Bordeaux, Bordeaux, BORDEAUX, France.ORCID http://orcid.org/0000-0002-4932-1484
Istvan SzikoraNational Institute of Clinical Neurosciences, Budapest, Hungary.
Denis HerbreteauCHU Tours, Tours, France.
Francis TurjmanCHU Lyon, Lyon, France.
Markus HoltmannspötterRigshospitalet, Copenhagen, Denmark.
Anne-Christine JanuelCHU Toulouse, Toulouse, France.
Vincent CostalatCHU Montpellier, Montpellier, France.
Jens FiehlerDepartrment of Neuroradiology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Joachim KlischHelios General Hospital, Erfurt, Germany.
Jean-Yves GauvritCHU Rennes, Rennes, France.
Werner WeberUniversitätsklinikum Knappschaftskrankenhaus Bochum GmbH, Bochum, Germany.
Hubert DesalCHU Nantes, Nantes, France.
Stéphane VelascoCHU Poitiers, Poitiers, France.
Thomas LiebigUniversitätsklinikum Köln, Cologne, Germany.
Luc StockxZOL(Ziekenhuis Oost-Limburg) Genk, Genk, Belgium.
Joachim BerkefeldInstitutfür Neuroradiologie, Klinikum der Johann Wolfgang Goethe-Universitaet, Frankfurt, Germany.
Andrew MolyneuxNuffield Department of Surgical Sciences, Oxford University, Oxford, UK.
James ByrneNuffield Department of Surgical Sciences, Oxford University, Oxford, UK.
Laurent SpelleHôpital Bicêtre, Assistance Publique-Hôpitaux de Paris, Kremlin-Bicêtre, France.
Assistance Publique – Hôpitaux de Paris · FRNuffield Orthopaedic Centre · GBCentre Hospitalier Universitaire de Bordeaux · FRCentre Hospitalier Universitaire de Montpellier · FRCentre Hospitalier Universitaire de Nantes · FRCentre Hospitalier Universitaire de Poitiers · FRCentre Hospitalier Universitaire de Reims · FRCentre Hospitalier Universitaire de Toulouse · FRCentre Hospitalier Universitaire de Tours · FRCentrum für Integrierte Onkologie · DEGoethe University Frankfurt · DEHelios Klinikum Erfurt · DEHospices Civils de Lyon · FRInstitut de Recherche en Informatique et Systèmes Aléatoires · FROrszágos Idegsebészeti Tudományos Intézet · HURigshospitalet · DKUniversität Hamburg · DEUniversitätsklinikum Knappschaftskrankenhaus Bochum · DEZiekenhuis Oost-Limburg · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundFlow disruption with the WEB is an innovative endovascular approach for treatment of wide-neck bifurcation aneurysms. Initial studies have shown a low complication rate with good efficacy. PURPOSE: To report clinical and anatomical results of the WEB treatment in the cumulative population of three Good Clinical Practice (GCP) studies: WEBCAST (WEB Clinical Assessment of Intrasaccular Aneurysm), French Observatory, and WEBCAST-2.

methodsWEBCAST, French Observatory, and WEBCAST-2 are single-arm, prospective, multicenter, GCP studies dedicated to the evaluation of WEB treatment. Clinical data were independently evaluated. Postoperative and 1-year aneurysm occlusion was independently evaluated using the 3-grade scale: complete occlusion, neck remnant, and aneurysm remnant.

resultsThe cumulative population comprised 168 patients with 169 aneurysms, including 112 female subjects (66.7%). The patients' ages ranged between 27 and 77 years (mean 55.5±10.2 years). Aneurysm locations were middle cerebral artery in 86/169 aneurysms (50.9%), anterior communicating artery in 36/169 (21.3%), basilar artery in 30/169 (17.8%), and internal carotid artery terminus in 17/169 (10.1%). The aneurysm was ruptured in 14/169 (8.3%). There was no mortality at 1 month and procedure/device-related morbidity was 1.2% (2/168). At 1 year, complete aneurysm occlusion was observed in 81/153 aneurysms (52.9%), neck remnant in 40/153 aneurysms (26.1%), and aneurysm remnant in 32/153 aneurysms (20.9%). Re-treatment was carried out in 6.9%.

conclusionsThis series is at the moment the largest prospective, multicenter, GCP series of patients with aneurysms treated with WEB. It shows the high safety and good mid-term efficacy of this treatment. CLINICAL

trial registrationFrench Observatory: Unique identifier (NCT18069); WEBCAST and WEBCAST-2: Unique identifier (NCT01778322).

Indexed as

Self Expandable Metallic StentsAdultAgedEmbolization, TherapeuticEndovascular ProceduresFemaleFranceHumansIntracranial AneurysmMaleMiddle AgedProspective StudiesTreatment Outcomeaneurysm

Identifiers

PMID28965106
PMCPMC5969386
OpenAlexW2757276209

What OpenQuestion holds

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LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.