ArticleThe Science of the total environment2018
High-throughput in-silico prediction of ionization equilibria for pharmacokinetic modeling.
Article in The Science of the total environment, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed.
- AI redefine untargeted metabolomics: estimating chemical amounts for a Human Exposome Project.Frontiers in public health · 2026Review
- Article
- Simulating toxicokinetic variability to identify susceptible and highly exposed populations.Journal of exposure science & environmental epidemiology · 2022Article
- Evaluation of a rapid, generic human gestational dose model.Reproductive toxicology (Elmsford, N.Y.) · 2022Article
- Using Chemical Structure Information to Develop Predictive Models forComputational toxicology (Amsterdam, Netherlands) · 2020Article
- Assessing Toxicokinetic Uncertainty and Variability in Risk Prioritization.Toxicological sciences : an official journal of the Society of Toxicology · 2019Article
- Open-source QSAR models for pKa prediction using multiple machine learning approaches.Journal of cheminformatics · 2019Article
- New Approach Methodologies for Exposure Science.Current opinion in toxicology · 2019Article
- Advancing Computational Toxicology in the Big Data Era by Artificial Intelligence: Data-Driven and Mechanism-Driven Modeling for Chemical Toxicity.Chemical research in toxicology · 2019Review
- Using the concordance of in vitro and in vivo data to evaluate extrapolation assumptions.PloS one · 2019Article
- Evaluating In Vitro-In Vivo Extrapolation of Toxicokinetics.Toxicological sciences : an official journal of the Society of Toxicology · 2018Article
- Evaluation and calibration of high-throughput predictions of chemical distribution to tissues.Journal of pharmacokinetics and pharmacodynamics · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
Abstract
Chemical ionization plays an important role in many aspects of pharmacokinetic (PK) processes such as protein binding, tissue partitioning, and apparent volume of distribution at steady state (Vd
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.