Evidence map›Paper›PMID 28964929›Full record

ArticleNeuroImage2017

Towards quantification of myelin by solid-state MRI of the lipid matrix protons.

Alan C Seifert, Cheng Li, Michael J Wilhelm, Suzanne L Wehrli, Felix W Wehrli

Open access · greenAbstract read
In one paragraph

Article in NeuroImage, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 50 citations in OpenAlex.

  1. Article
  2. Brain short TNeuroImage · 2025
    Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Mapping the myelin bilayer with short-TMagnetic resonance in medicine · 2023
    Article
  11. Ultra-short TMagnetic resonance in medicine · 2023
    Article
  12. Article
  13. Review
  14. Article
  15. Brain ultrashort TJournal of magnetic resonance (San Diego, Calif. : 1997) · 2021
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Alan C SeifertLaboratory for Structural, Physiologic and Functional Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 1 Founders Pavilion, 3400 Spruce Street, Philadelphia, PA 19104, USA. Electronic address: alan.seifert@mssm.edu.
Cheng LiLaboratory for Structural, Physiologic and Functional Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 1 Founders Pavilion, 3400 Spruce Street, Philadelphia, PA 19104, USA.
Michael J WilhelmDepartment of Chemistry, Temple University, 1901 N. 13th St., Philadelphia, PA 19122, USA.
Suzanne L WehrliSAIF Core Facility, The Children's Hospital of Philadelphia, Room 413 Abramson Building, 34th Street and Civic Center Boulevard, Philadelphia, PA 19104, USA.
Felix W WehrliLaboratory for Structural, Physiologic and Functional Imaging, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, 1 Founders Pavilion, 3400 Spruce Street, Philadelphia, PA 19104, USA. Electronic address: wehrli@mail.med.upenn.edu.
University of Pennsylvania · USChildren's Hospital of Philadelphia · USTemple University · US

Funding

Feasibility of Direct Quantitative Magnetic Resonance Imaging of MyelinR21NS082953 · NINDS · UNIVERSITY OF PENNSYLVANIA · PI WEHRLI, FELIX W · 2013 to 2014
$456k
NINDS NIH HHS R21 NS082953
6 · The paper itself

Abstract

purposeDirect assessment of myelin has the potential to reveal central nervous system abnormalities and serve as a means to follow patients with demyelinating disorders during treatment. Here, we investigated the feasibility of direct imaging and quantification of the myelin proton pool, without the many possible confounds inherent to indirect methods, via long-T

methodsZTE and UTE experiments, with and without inversion-recovery (IR) preparation, were conducted in ovine spinal cords before and after D

resultsMR signal amplitudes from reference samples at 9.4T were linearly correlated with myelin concentration (R

conclusionIn the present implementation, IR-UTE at 9.4T produced similar estimates of myelin concentration in D

Indexed as

Myelin SheathAnimalsImage Processing, Computer-AssistedLipidsMagnetic Resonance ImagingProtonsSheepSpinal CordLipidsProtonsLong-T2 suppressionMRIMyelinUTEWhite matterZTE

Identifiers

PMID28964929
PMCPMC5716915
OpenAlexW2759802903

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.