Evidence map›Paper›PMID 28964831›Full record

ArticleBiochimie2017

Discovery of novel non-competitive inhibitors of mammalian neutral M1 aminopeptidase (APN).

Isel Pascual, Pedro A Valiente, Gabriela García, Mario E Valdés-Tresanco, Yarini Arrebola, Lisset Díaz, Lotfi Bounaadja, Rosa María Uribe, Mae Chappé Pacheco, Isabelle Florent and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochimie, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 3 countries.

Isel PascualCenter for Protein Studies, Faculty of Biology, University of Havana, Cuba. Electronic address: isel@fbio.uh.cu.
Pedro A ValienteCenter for Protein Studies, Faculty of Biology, University of Havana, Cuba. Electronic address: valiente@fbio.uh.cu.
Gabriela GarcíaCenter for Protein Studies, Faculty of Biology, University of Havana, Cuba. Electronic address: gabrielagr1991@gmail.com.
Mario E Valdés-TresancoCenter for Protein Studies, Faculty of Biology, University of Havana, Cuba. Electronic address: mevaldes@fbio.uh.cu.
Yarini ArrebolaCenter for Protein Studies, Faculty of Biology, University of Havana, Cuba. Electronic address: yarinimanuel@fbio.uh.cu.
Lisset DíazCenter for Protein Studies, Faculty of Biology, University of Havana, Cuba. Electronic address: lisset@fbio.uh.cu.
Lotfi BounaadjaMolécules de Communication et Adaptation des Microorganismes, (MCAM, UMR 7245), Muséum National Histoire Naturelle, Sorbonne Universités, CNRS, CP 52, 57 Rue Cuvier, 75005, Paris, France. Electronic address: lotfi.bounaadja@mnhn.fr.
Rosa María UribeInstituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), Ave Universidad 2001, Cuernavaca, Morelos, Mexico. Electronic address: rosa@ibt.unam.mx.
Mae Chappé PachecoInstituto de Oncología y Radiobiología, Habana, Cuba. Electronic address: mchappep@gmail.com.
Isabelle FlorentMolécules de Communication et Adaptation des Microorganismes, (MCAM, UMR 7245), Muséum National Histoire Naturelle, Sorbonne Universités, CNRS, CP 52, 57 Rue Cuvier, 75005, Paris, France. Electronic address: isabelle.florent@mnhn.fr.
Jean-Louis CharliInstituto de Biotecnología, Universidad Nacional Autónoma de México (UNAM), Ave Universidad 2001, Cuernavaca, Morelos, Mexico. Electronic address: charli@ibt.unam.mx.
University of Havana · CUMolécules de Communication et Adaptation des Micro-organismes · FRUniversidad Nacional Autónoma de México · MXInstituto de Oncología y Radiobiología · CU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neutral metallo-aminopeptidase (APN) catalyzes the cleavage of neutral and basic amino acids from the N-terminus of protein or peptide substrates. APN expression is dysregulated in inflammatory diseases as well as in several types of cancer. Therefore, inhibitors of APN may be effective against cancer and inflammation. By virtual screening and enzymatic assays, we identified three non-competitive inhibitors (α > 1) of the porcine and human APN with K

Indexed as

AminopeptidasesAnimalsEnzyme InhibitorsHumansMolecular Docking SimulationOrgan SpecificityProtein ConformationRatsSwineZincAminopeptidasesEnzyme InhibitorsZincIn vivo inhibitionM1 familyNeutral aminopeptidaseNon-competitive inhibitorsVirtual screening

Identifiers

PMID28964831
PMCPMC7127808
OpenAlexW2757727107

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.