Evidence map›Paper›PMID 28964786›Full record

ArticleCancer letters2017

Multiparity activates interferon pathways in peritoneal adipose tissue and decreases susceptibility to ovarian cancer metastasis in a murine allograft model.

Elizabeth A Loughran, Ryan C Phan, Annemarie K Leonard, Laura Tarwater, Marwa Asem, Yueying Liu, Jing Yang, Yuliya Klymenko, Jeff Johnson, Zonggao Shi and 5 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancer letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Elizabeth A LoughranDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA; Integrated Biomedical Sciences Graduate Program, University of Notre Dame, Notre Dame, IN, USA; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.
Ryan C PhanHarper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.
Annemarie K LeonardDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.
Laura TarwaterHarper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.
Marwa AsemDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA; Integrated Biomedical Sciences Graduate Program, University of Notre Dame, Notre Dame, IN, USA; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.
Yueying LiuDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.
Jing YangDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.
Yuliya KlymenkoDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.
Jeff JohnsonDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.
Zonggao ShiHarper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.
Tyvette S HilliardDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.
Marielle BlumenthalerHarper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.
Matthew LeevyDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA.
Matthew J RavosaDepartment of Biological Sciences, University of Notre Dame, Notre Dame, IN, USA; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA; Department of Aerospace and Mechanical Engineering, University of Notre Dame, Notre Dame, IN, USA; Department of Anthropology, University of Notre Dame, Notre Dame, IN, USA.
M Sharon StackDepartment of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, IN, USA; Harper Cancer Research Institute, University of Notre Dame, Notre Dame, IN, USA. Electronic address: sstack@nd.edu.
University of Notre Dame · US

Funding

Receptor Cross-Talk in Early Metastatic DisseminationR01CA109545 · NCI · UNIVERSITY OF NOTRE DAME · PI STACK, MARY SHARON · 2006 to 2022
$4.3M
REGULATION OF OVARIAN CARCINOMA PROTEINASESR01CA086984 · NCI · UNIVERSITY OF NOTRE DAME · PI STACK, MARY SHARON · 2000 to 2014
$3.8M
NCI NIH HHS R01 CA086984NCI NIH HHS R01 CA109545
6 · The paper itself

Abstract

Ovarian cancer is the fifth leading cause of cancer deaths in U.S. women and the deadliest gynecologic malignancy. This lethality is largely due to the fact that most cases are diagnosed at metastatic stages of the disease when the prognosis is poor. Epidemiologic studies consistently demonstrate that parous women have a reduced risk of developing ovarian cancer, with a greater number of births affording greater protection; however little is known about the impact of parity on ovarian cancer metastasis. Here we report that multiparous mice are less susceptible to ovarian cancer metastasis in an age-matched syngeneic murine allograft model. Interferon pathways were found to be upregulated in healthy adipose tissue of multiparous mice, suggesting a possible mechanism for the multiparous-related protective effect against metastasis. This protective effect was found to be lost with age. Based on this work, future studies exploring therapeutic strategies which harness the multiparity-associated protective effect demonstrated here are warranted.

Indexed as

ParityAdipose TissueAllograftsAnimalsCarcinoma, Ovarian EpithelialDisease Models, AnimalDisease SusceptibilityFemaleInterferonsMiceMice, Inbred C57BLNeoplasm MetastasisNeoplasms, Glandular and EpithelialNeoplasm TransplantationOvarian NeoplasmsPeritoneal NeoplasmsInterferonsAdipose tissueInterferons (IFNs)Murine age-matched model of parityOvarian cancer metastasisParity

Identifiers

PMID28964786
PMCPMC6317723
OpenAlexW2759619618

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.