Evidence map›Paper›PMID 28964291›Full record

ArticleInternational journal of pediatric otorhinolaryngology2017

HIV status and hearing loss among children between 6 and 12 years of age at a large urban health facility in south western Uganda.

Doreen Nakku, Victoria Nyaiteera, Evelyn Llowet, Dennis Nanseera, Gladys Nakalema, Brian Westerberg, Francis Bajunirwe

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of pediatric otorhinolaryngology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
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  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Doreen NakkuDepartment of Ear, Nose and Throat, Mbarara University of Science and Technology, P.O Box 1410, Mbarara, Uganda. Electronic address: daurynez@gmail.com.
Victoria NyaiteeraDepartment of Ear, Nose and Throat, Mbarara University of Science and Technology, P.O Box 1410, Mbarara, Uganda.
Evelyn LlowetDepartment of Ear, Nose and Throat, Mbarara University of Science and Technology, P.O Box 1410, Mbarara, Uganda.
Dennis NanseeraPediatric HIV Clinic, Mbarara Regional Referral Hospital, P.O Box 40, Mbarara, Uganda.
Gladys NakalemaDepartment of Educational Psychology, Mbarara University of Science and Technology, P.O Box 1410, Mbarara, Uganda.
Brian WesterbergDivision of Otology and Neurotology, University of British Columbia, St. Paul's Hospital, 1081 Burrard Street, Vancouver, BC, Canada.
Francis BajunirweDepartment of Community Health, Mbarara University of Science and Technology, P.O Box 1410, Mbarara, Uganda.
Mbarara University of Science and Technology · UGMbarara National Referral Hospital · UGUniversity of British Columbia · CA

Funding

Mbarara University Research Training Initiative (MURTI)D43TW010128 · FIC · MBARARA UNIVERSITY/SCIENCE/ TECHNOLOGY · PI OBUA, CELESTINO · 2015 to 2019
$3.5M
FIC NIH HHS D43 TW010128
6 · The paper itself

Abstract

introductionPediatric HIV infection and treatment may increase the risk for hearing loss (HL), both sensorineural (SNHL) and conductive hearing loss (CHL). There is limited data on this subject, especially from sub Saharan Africa. The aim of this study was therefore to compare the prevalence of hearing loss among HIV positive and negative children, to determine the types of hearing loss and whether Nevirapine (NVP) based antiretroviral therapy (ART) is associated with HL.

methodsWe conducted a cross sectional study at two tertiary health facilities in south western Uganda. We consecutively enrolled 79 HIV negative and 148 HIV positive children aged between 6 and 12 years. Inclusion criteria were completion of written consent, ability to follow instructions to perform an audiogram and absence of congenital HL. We conducted hearing screening using the iPad Shoebox

resultsOf the 227 children enrolled, 115 (50.7%) were female. The mean age was 9.2 years (median = 9). Based on self-report, frequency of HL among HIV positive children was 6.8% and 20.3% among HIV negative children (p=<0.01). Using objective measures, prevalence of HL among the HIV positive children was 8.8% compared to 10.1% among the HIV negative children (p = 0.74). CHL was generally more frequent than SNHL but SNHL occurred more frequently among HIV positive (7.4%) compared to HIV negative children (3.8%). No association was found between NVP based ART and HL (p = 0.41). Logistic regression showed that older age of the child (p = 0.01), previous ear infection (p=<0.01), tuberculosis (TB) treatment (p=<0.01) and long term duration on ART (p=<0.01) were significantly associated with HL. Age (p = 0.02), previous ear infection (p = 0.01) and TB treatment (p = 0.005) remained significant in the multiple regression model.

conclusionPrevalence of HL is similar among HIV positive and negative children. Older age of the child, previous ear infection, use of TB drugs and long duration on ART among the HIV positive children increase the odds of having hearing loss among children. However, use of NVP was not associated with HL.

Indexed as

Anti-Retroviral AgentsAudiometry, Pure-ToneChildCross-Sectional StudiesFemaleHearing LossHIV InfectionsHumansMaleNevirapinePrevalenceUgandaAnti-Retroviral AgentsNevirapineChildrenHearing lossHIVNevirapine

Identifiers

PMID28964291
PMCPMC5659749
OpenAlexW2746180510

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.