ArticleChaos (Woodbury, N.Y.)2017
Modeling dynamics in diseased cardiac tissue: Impact of model choice.
Article in Chaos (Woodbury, N.Y.), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Computational modeling of cardiac electrophysiology and arrhythmogenesis: toward clinical translation.Physiological reviews · 2024Review
- Fibrosis modeling choice affects morphology of ventricular arrhythmia in non-ischemic cardiomyopathy.Frontiers in physiology · 2024Article
- Biomimetic Cardiac Tissue Models for In Vitro Arrhythmia Studies.Biomimetics (Basel, Switzerland) · 2023Review
- The physics of heart rhythm disorders.Physics reports · 2022Article
- Identifying locations susceptible to micro-anatomical reentry using a spatial network representation of atrial fibre maps.PloS one · 2022Article
- A Review of Healthy and Fibrotic Myocardium Microstructure Modeling and Corresponding Intracardiac Electrograms.Frontiers in physiology · 2022Review
- Bidomain modeling of electrical and mechanical properties of cardiac tissue.Biophysics reviews · 2021Review
- Using Machine Learning to Characterize Atrial Fibrotic Substrate From Intracardiac Signals With a HybridFrontiers in physiology · 2021Article
- Unified mechanism of local drivers in a percolation model of atrial fibrillation.Physical review. E · 2019Article
- Normal and fibrotic liver parenchyma respond differently to irreversible electroporation.HPB : the official journal of the International Hepato Pancreato Biliary Association · 2019Article
- Understanding AF Mechanisms Through Computational Modelling and Simulations.Arrhythmia & electrophysiology review · 2019Review
- Microheterogeneity-induced conduction slowing and wavefront collisions govern macroscopic conduction behavior: A computational and experimental study.PLoS computational biology · 2018Article
- Heart Rhythm Insights Into Structural Remodeling in Atrial Tissue: Timed Automata Approach.Frontiers in physiology · 2018Article
- Dispersion of Recovery and Vulnerability to Re-entry in a Model of Human Atrial Tissue With Simulated Diffuse and Focal Patterns of Fibrosis.Frontiers in physiology · 2018Article
- Understanding the transition from paroxysmal to persistent atrial fibrillation.Physical review researchArticle
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cardiac arrhythmias have been traditionally simulated using continuous models that assume tissue homogeneity and use a relatively large spatial discretization. However, it is believed that the tissue fibrosis and collagen deposition, which occur on a micron-level, are critical factors in arrhythmogenesis in diseased tissues. Consequently, it remains unclear how well continuous models, which use averaged electrical properties, are able to accurately capture complex conduction behaviors such as re-entry in fibrotic tissues. The objective of this study was to compare re-entrant behavior in discrete microstructural models of fibrosis and in two types of equivalent continuous models, a homogenous continuous model and a hybrid continuous model with distinct heterogeneities. In the discrete model, increasing levels of tissue fibrosis lead to a substantial increase in the re-entrant cycle length which is inadequately reflected in the homogenous continuous models. These cycle length increases appear to be primarily due to increases in the tip path length and to altered restitution behavior, and suggest that it is critical to consider the discrete effects of fibrosis on conduction when studying arrhythmogenesis in fibrotic myocardium. Hybrid models are able to accurately capture some aspects of re-entry and, if carefully tuned, may provide a framework for simulating conduction in diseased tissues with both accuracy and efficiency.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.