Evidence map›Paper›PMID 28963927›Full record

ArticleNuclear medicine and biology2017

Human biodistribution and dosimetry of [

Tobey J Betthauser, Ansel T Hillmer, Patrick J Lao, Emily Ehlerding, Jogeshwar Mukherjee, Charles K Stone, Bradley T Christian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nuclear medicine and biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Reduction in [Brain research · 2025
    Article
  2. Article
  3. Article
  4. Radiosynthesis and characterization of [European journal of nuclear medicine and molecular imaging · 2021
    Article
  5. Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Tobey J BetthauserDepartment of Medical Physics, University of Wisconsin - Madison School of Medicine and Public Health, Madison, WI, USA; Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin - Madison School of Medicine and Public Health, Madison, WI, USA. Electronic address: tbetthauser@wisc.edu.
Ansel T HillmerDepartments of Radiology and Biomedical Imaging, Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Patrick J LaoDepartment of Medical Physics, University of Wisconsin - Madison School of Medicine and Public Health, Madison, WI, USA; Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin - Madison School of Medicine and Public Health, Madison, WI, USA.
Emily EhlerdingDepartment of Medical Physics, University of Wisconsin - Madison School of Medicine and Public Health, Madison, WI, USA.
Jogeshwar MukherjeePreclinical Imaging, Department of Radiological Sciences, University of California - Irvine, Irvine, CA, USA.
Charles K StoneDepartment of Medicine, University of Wisconsin - Madison School of Medicine and Public Health, Madison, WI, USA.
Bradley T ChristianDepartment of Medical Physics, University of Wisconsin - Madison School of Medicine and Public Health, Madison, WI, USA; Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin - Madison School of Medicine and Public Health, Madison, WI, USA.
University of Wisconsin–Madison · USUniversity of California, Irvine · USYale University · US

Funding

U.W. RADIOLOGICAL SCIENCES TRAINING PROGRAMT32CA009206 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Bryan Patrick Bednarz · 1985 to 2026
$12.1M
Chemistry-Biology Interface Training ProgramT32GM008505 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI BLACKWELL, HELEN E. · 1993 to 2023
$9.8M
Waisman Intellectual and Developmental Disabilities Research Center Down Syndrome RegistryU54HD090256 · NICHD · UNIVERSITY OF WISCONSIN-MADISON · PI CHANG, QIANG · 2016 to 2020
$6.0M
PET Imaging Agents for Nicotinic a4b2 ReceptorsR01AG029479 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI MUKHERJEE, JOGESHWAR · 2007 to 2017
$2.6M
PET Imaging agents for a4b2 Nicotinic ReceptorsRF1AG029479 · NIA · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHRISTIAN, BRADLEY T, MUKHERJEE, JOGESHWAR · 2019 to 2020
$2.2M
NCI NIH HHS T32 CA009206NIA NIH HHS R01 AG029479NIA NIH HHS RF1 AG029479NICHD NIH HHS U54 HD090256NIGMS NIH HHS T32 GM008505
6 · The paper itself

Abstract

introductionThe α4β2* nicotinic acetylcholine receptor (nAChR) system is implicated in many neuropsychiatric pathologies. [

methodsFour human subjects (2M, 2F) underwent whole-body PET/CT scans to determine the human biodistribution of [

results[

conclusions[ ADVANCES IN KNOWLEDGE AND IMPLICATIONS FOR PATIENT CARE: This works presents human internal dosimetry for [

Indexed as

AnimalsFemaleHumansMaleMicePositron Emission Tomography Computed TomographyPyridinesPyrrolesRadiochemistryRadiometryReceptors, NicotinicTissue DistributionWhole Body Imagingnicotinic receptor alpha4beta2nifenePyridinesPyrrolesReceptors, NicotinicDosimetryNicotinic acetylcholinePositron emission tomography

Identifiers

PMID28963927
PMCPMC5709231
OpenAlexW2749063204

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.