Evidence map›Paper›PMID 28963849›Full record

ArticleFEBS letters2017

Effect of endosomal acidification on small ion transport through the anthrax toxin PA

Nnanya Kalu, Antonio Alcaraz, Goli Yamini, Sanaz Momben Abolfath, Laura Lucas, Clare Kenney, Vicente M Aguilella, Ekaterina M Nestorovich

Open access · bronzeAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS letters, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 11 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Nnanya KaluDepartment of Biology, The Catholic University of America, Washington, DC, USA.
Antonio AlcarazLaboratory of Molecular Biophysics, Department of Physics, Universitat Jaume I, Castellón, Spain.
Goli YaminiDepartment of Biology, The Catholic University of America, Washington, DC, USA.
Sanaz Momben AbolfathDepartment of Biology, The Catholic University of America, Washington, DC, USA.
Laura LucasDepartment of Biology, The Catholic University of America, Washington, DC, USA.
Clare KenneyDepartment of Biology, The Catholic University of America, Washington, DC, USA.
Vicente M AguilellaLaboratory of Molecular Biophysics, Department of Physics, Universitat Jaume I, Castellón, Spain.
Ekaterina M NestorovichDepartment of Biology, The Catholic University of America, Washington, DC, USA.
Catholic University of America · USUniversitat Jaume I · ESUniversity of America · US

Funding

OBSTRUCTING TOXIN'S PATHWAYS: UNIVERSAL INHIBITORS OF BINARY BACTERIAL TOXINSR15AI099897 · NIAID · CATHOLIC UNIVERSITY OF AMERICA · PI NESTOROVICH, EKATERINA · 2014 to 2014
$423k
NIAID NIH HHS R15 AI099897
6 · The paper itself

Abstract

Tight regulation of pH is critical for the structure and function of cells and organelles. The pH environment changes dramatically along the endocytic pathway, an internalization transport process that is 'hijacked' by many intracellularly active bacterial exotoxins, including the anthrax toxin. Here, we investigate the role of pH on single-channel properties of the anthrax toxin protective antigen (PA

Indexed as

AnimalsAntigens, BacterialBacterial ToxinsCell LineEndosomesHumansHydrogen-Ion ConcentrationIon ChannelsIon Transportanthrax toxinAntigens, BacterialBacterial ToxinsIon Channelsaccess resistanceBacillus anthraciscurrent fluctuationsendosomal acidificationmultistate conductance

Identifiers

PMID28963849
PMCPMC5683923
OpenAlexW2758939156

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.