ArticleJournal of veterinary internal medicine2017
Long-term Treatment with Methylene Blue in a Dog with Hereditary Methemoglobinemia Caused by Cytochrome b5 Reductase Deficiency.
Article in Journal of veterinary internal medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 25 citations in OpenAlex.
- Preliminary investigation of circulating methaemoglobin fraction in cats with sepsis: a small exploratory study.Journal of feline medicine and surgery · 2026Article
- Oxidative hemolytic crises in a dog due to fragrance products: clinical insights and treatment approaches.Journal of veterinary science · 2024Article
- Methemoglobinemia, Increased Deformability and Reduced Membrane Stability of Red Blood Cells in a Cat with aCells · 2023Article
- Suspected Drinking Water Poisoning in a Domestic Kitten with Methemoglobinemia.Veterinary sciences · 2021Article
- Methemoglobin formation in mutant hemoglobin α chains: electron transfer parameters and rates.Biophysical journal · 2021Article
- Characterization of a novel nicotinamide adenine dinucleotide-cytochrome b5 reductase mutation associated with canine hereditary methemoglobinemia.The Journal of veterinary medical science · 2021Article
- Clinical, metabolic, and molecular genetic characterization of hereditary methemoglobinemia caused by cytochrome bScientific reports · 2020Article
- Circulating Methemoblogin Fraction in Dogs With Sepsis.Frontiers in veterinary science · 2020Article
- Clinical, metabolic, and genetic characterization of hereditary methemoglobinemia caused by cytochrome bJournal of veterinary internal medicine · 2019Article
- Hereditary methemoglobinemia in a cyanotic cat presented for ovariohysterectomy.The Canadian veterinary journal = La revue veterinaire canadienne · 2019Article
- Genetic cause for congenital methemoglobinemia in an Australian Pomeranian dog.Journal of veterinary internal medicine · 2019Article
- Methemoglobin Modulation as an Intravascular Contrast Agent for Magnetic Resonance Imaging: Proof of Concept.Frontiers in veterinary science · 2019Article
- Transient methemoglobinemia suspected secondary to ingestion ofVeterinary medicine (Auckland, N.Z.) · 2019Article
- Familial Congenital Methemoglobinemia in Pomeranian Dogs Caused by a Missense Variant in the NADH-Cytochrome B5 Reductase Gene.Journal of veterinary internal medicine · 2018Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A juvenile male mixed breed dog was presented for lethargy, exercise intolerance, and aggression when touched on the head. Cyanosis, tachycardia, and tachypnea were observed and persisted during oxygen supplementation. Arterial blood gas analysis by co-oximetry identified an increased methemoglobin concentration (27%; normal, <2%) with normal arterial oxygen tension. The methemoglobinemia and associated clinical signs resolved after administration of methylene blue (1 mg/kg) IV, and the dog was discharged. The affected dog's whole-genome sequence contained 2 potentially causal heterozygous CYB5R3 missense mutations suggesting that cytochrome b5 reductase deficiency was responsible for the methemoglobinemia. This hypothesis was confirmed by enzyme analysis that identified cytochrome b5 reductase activity in the affected dog's erythrocytes to only approximately 6% of that in a control sample. Clinical signs recurred 11 days after discharge but normalized and the methemoglobin concentration decreased with methylene blue administration PO (1.5 mg/kg, initially daily and then every other day).
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