ReviewEuropean journal of pediatrics2018
Clinical Practice: Nausea and vomiting in acute gastroenteritis: physiopathology and management.
Review in European journal of pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 26 citations in OpenAlex.
- Effect of ondansetron on vomiting associated with acute gastroenteritis in a developing country: a meta-analysis.European journal of pediatrics · 2020Pooled it
- Single-dose of ondansetron for vomiting in children and adolescents with acute gastroenteritis-an updated systematic review and meta-analysis.European journal of pediatrics · 2020Pooled it
- Pooled it
- Efficacy of ginger as antiemetic in children with acute gastroenteritis: a randomised controlled trial.Alimentary pharmacology & therapeutics · 2021Trial
- Italian multidisciplinary delphi consensus on home management of nausea and vomiting in children with acute gastroenteritis (NoEmesi Project).Frontiers in pediatrics · 2026Article
- Sensory signals for nausea.Trends in neurosciences · 2025Review
- Acetonemic vomiting: a potential complication of treatment with glucagon-like peptide-1 receptor agonists especially in lean type 2 diabetes patients.Diabetology international · 2025Article
- Eu- or hypoglycemic ketosis and ketoacidosis in children: a review.Pediatric nephrology (Berlin, Germany) · 2024Review
- Article
- Gut dysmotility in children with neurological impairment: the nutritional management.Frontiers in neurology · 2023Review
- Alterations and diagnostic performance of capillary ketonemia in pediatric acute appendicitis: a pilot study.Pediatric surgery international · 2022Article
- Outdoor temperature and circulating sodium in children with acute gastroenteritis.Pediatric research · 2022Article
- Vomiting and hyperkalemia are novel clues for emergency room diagnosis of type 1 diabetic ketoacidosis: a retrospective comparison between diabetes types.Diabetology international · 2022Article
- Treatment with Oral Ondansetron for Ultramarathon-Associated Nausea: The TOO FUN Study.Sports (Basel, Switzerland) · 2021Article
- Maintenance Fluid Therapy with Saline, Dextrose-Supplemented Saline or Lactated Ringer in Childhood: Short-Term Metabolic Effects.Nutrients · 2020Observational
- Survey of nil per os duration of patients admitted to the emergency department due to vomiting.Medicine · 2019Observational
- Guiding Ketogenic Diet with Breath Acetone Sensors.Sensors (Basel, Switzerland) · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Currently recommended management of acute gastroenteritis is supportive. Although the affected children habitually have vomiting, recommendations do not focus on the correction of this symptom. In this condition, elevated ketone bodies and stimuli initiated by gut mucosa damage produced by the enteral pathogen likely underlay nausea and vomiting. As compared to 0.9% saline, intravenous administration of a dextrose-containing bolus of 0.9% saline is associated with a greater reduction of circulating ketones and a shorter duration of nausea and vomiting. Nonetheless, this treatment strategy is not followed by a lower rate of hospitalization.
conclusionWell-designed investigations suggest that antagonists of the type 3 serotonin receptor, most frequently oral ondansetron, reduce the rate of vomiting, improve the tolerance of oral rehydration, and reduce the need for intravenous rehydration. What is Known: • Although children with gastroenteritis habitually have vomiting, current recommendations do not focus on the correction of this symptom. What is New: • Recently acquired evidence supports the prescription of ondansetron, an antagonist of the type 3 serotonin receptor, to increase the success rate of oral rehydration therapy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.