Evidence map›Paper›PMID 28963615›Full record

ArticleThe journal of headache and pain2017

Brain networking analysis in migraine with and without aura.

Marina de Tommaso, Gabriele Trotta, Eleonora Vecchio, Katia Ricci, R Siugzdaite, Sebastiano Stramaglia

2 registry-linked trialsOpen access · goldAbstract read
In one paragraph

Article in The journal of headache and pain, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06155123 unknown statusnot on this mapstarted 2020, after this paper: background citation

High-density EEG Evaluation of Functional Connectivity Changes in Migraine Patients Receiving Advanced Preventive Therapies (Anti-CGRP mAbs)

Typeobservational_patient_registrySponsorIRCCS National Neurological Institute "C. Mondino" FoundationRan2020 to 2024Enrolled60ConditionsMigraine Disorders, Chronic Migraine, Episodic MigraineArmsMonoclonal antibody targeting the CGRP pathway (ligand or receptor) (mAbs)
NCT06206772 unknown statusnot on this mapstarted 2021, after this paper: background citation

The Role of Resting State Networks Connectivity in Cluster Headache: a HD-EEG Study

TypeobservationalSponsorIRCCS National Neurological Institute "C. Mondino" FoundationRan2021 to 2025Enrolled20ConditionsCluster Headache, Headache DisordersArmsResting state HD-EEG recording
3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 45 citations in OpenAlex.

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  10. Application of EEG in migraine.Frontiers in human neuroscience · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Marina de TommasoApplied Neurophysiology and Pain Unit, Basic Medical, Neuroscience and Sensory System -SMBNOS- Department, Bari Aldo Moro University, Giovanni XXIII Building, Policlinico General Hospital, Via Amendola 207 A, 70124, Bari, Italy. marina.detommaso@uniba.it.
Gabriele TrottaPhysic Department, Bari Aldo Moro University, Bari, Italy.
Eleonora VecchioApplied Neurophysiology and Pain Unit, Basic Medical, Neuroscience and Sensory System -SMBNOS- Department, Bari Aldo Moro University, Giovanni XXIII Building, Policlinico General Hospital, Via Amendola 207 A, 70124, Bari, Italy.
Katia RicciApplied Neurophysiology and Pain Unit, Basic Medical, Neuroscience and Sensory System -SMBNOS- Department, Bari Aldo Moro University, Giovanni XXIII Building, Policlinico General Hospital, Via Amendola 207 A, 70124, Bari, Italy.
R SiugzdaiteData Analysis Department, Faculty of Psychological and Pedagogical Sciences 1, Ghent University, Ghent, Belgium.
Sebastiano StramagliaPhysic Department, Bari Aldo Moro University, Bari, Italy.
Ospedale Pediatrico Giovanni XXIII · ITUniversity of Bari Aldo Moro · ITGhent University · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo apply effective connectivity by means of nonlinear Granger Causality (GC) and brain networking analysis to basal EEG and under visual stimulation by checkerboard gratings with 0.5 and 2.0 cpd as spatial frequency in migraine with aura (MA) and without aura (MO), and to compare these findings with Blood Oxygen Level Dependent (BOLD) signal changes.

methodsNineteen asymptomatic MA and MO patients and 11 age and sex matched controls (C) were recorded by 65 EEG channels. The same visual stimulation was employed to evaluate BOLD signal changes in a subgroup of MA and MO. The GC and brain networking were applied to EEG signals.

resultsA different pattern of reduced vs increased GC respectively in MO and MA patients, emerged in resting state. During visual stimulation, both MA and MO showed increased information transfer toward the fronto-central regions, while MA patients showed a segregated cluster of connections in the posterior regions, and an increased bold signal in the visual cortex, more evident at 2 cpd spatial frequency.

conclusionsThe wealth of information exchange in the parietal-occipital regions indicates a peculiar excitability of the visual cortex, a pivotal condition for the manifestation of typical aura symptoms.

Indexed as

AdolescentAdultCerebral CortexConnectomeElectroencephalographyFemaleHumansMagnetic Resonance ImagingMaleMigraine with AuraMigraine without AuraMotion PerceptionPattern Recognition, VisualYoung AdultEEGGranger causalityMigraine with Aura

Identifiers

PMID28963615
PMCPMC5622013
OpenAlexW2759943737

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.