Evidence map›Paper›PMID 28963591›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2018

Eight-week, multimodal exercise counteracts a progress of chemotherapy-induced peripheral neuropathy and improves balance and strength in metastasized colorectal cancer patients: a randomized controlled trial.

Philipp Zimmer, Sina Trebing, Ursula Timmers-Trebing, Alexander Schenk, Rainer Paust, Wilhelm Bloch, Roland Rudolph, Fiona Streckmann, Freerk T Baumann

4 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 123 papers, 20 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
123citing papers in PubMed, 20 pooled it
6.9field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03798379 nacompletednot on this map

The Effect of Therapeutic Exercises on Balance, Quality of Life and Pain in Patients Who Were Receiving Neurotoxic Chemotherapy

TypeinterventionalSponsorHitit UniversityRan2015 to 2016Enrolled60ConditionsChemotherapy-induced Peripheral NeuropathyArmsExercise
NCT05114005 nacompletednot on this mapstarted 2021, after this paper: background citation

Dance-Based Avenues to Advance Nonpharmacologic Treatment of Chemotherapy Effects (DAANCE)

TypeinterventionalSponsorOhio State University Comprehensive Cancer CenterRan2021 to 2024Enrolled52ConditionsCancer, Breast, NeuropathyArmsRhythmic Auditory Stimulation, Evidence-Based Exercise
NCT06696976 nanot yet recruitingnot on this mapstarted 2024, after this paper: background citation

Effects of Telerehabilitation Versus Clinical Rehabilitation on Neuropathic Pain, Physical Function and Quality of Life in Chemotherapy Induced Peripheral Neuropathy

TypeinterventionalSponsorRiphah International UniversityRan2024 to 2025Enrolled66ConditionsChemotherapy Induced Peripheral NeuropathyArmsTelerehabilitation, Clinical rehabilitation
NCT07632482 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

Effects of Dance-based Multimodal Exercise Programme for Managing Chemotherapy-induced Peripheral Neuropathy in Patients With Solid Tumors: A Pilot Randomized Controlled Study

TypeinterventionalSponsorChinese University of Hong KongRan2026 to 2026Enrolled76ConditionsCancerArmsdance-based multimodal exercise, Exercise education
3 · Its place in the literature

Who cites it

123 citing papers in PubMed, 20 syntheses or guidelines pooled it, 214 citations in OpenAlex.

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  2. Non-pharmacological interventions targeting mobility among people with advanced cancer: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
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  6. Effect of exercise interventions in adults with cancer receiving palliative care: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2023
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  18. The effects of exercise on chemotherapy-induced peripheral neuropathy symptoms in cancer patients: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2021
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63 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Philipp ZimmerDepartment for Molecular and Cellular Sports Medicine, German Sports University Cologne, Am Sportpark Müngersdorf 6, 50933, Cologne, Germany. p.zimmer@dshs-koeln.de.
Sina TrebingDepartment for Molecular and Cellular Sports Medicine, German Sports University Cologne, Am Sportpark Müngersdorf 6, 50933, Cologne, Germany.
Ursula Timmers-TrebingVGSU Essen, Association for Health Related Fitness and Sports Therapy at University Duisburg-Essen, Henri-Dunant-Str. 65, 45131, Essen, Germany.
Alexander SchenkDepartment for Molecular and Cellular Sports Medicine, German Sports University Cologne, Am Sportpark Müngersdorf 6, 50933, Cologne, Germany.
Rainer PaustContilia Group, Institute for Psychosocial Medicine, Klara-Klopp-Weg 1, 45138, Essen, Germany.
Wilhelm BlochDepartment for Molecular and Cellular Sports Medicine, German Sports University Cologne, Am Sportpark Müngersdorf 6, 50933, Cologne, Germany.
Roland RudolphOutpatient Tumor Centre Essen, Henricistr. 40, 45136, Essen, Germany.
Fiona StreckmannDepartment for Molecular and Cellular Sports Medicine, German Sports University Cologne, Am Sportpark Müngersdorf 6, 50933, Cologne, Germany.
Freerk T BaumannDepartment I of Internal Medicine, Center for Integrated Oncology Cologne Bonn, University Hospital of Cologne, Kerpener Str. 62, 50937, Cologne, Germany.
German Sport University Cologne · DEEssen University Hospital · DEKlinik für Psychosomatik · DEUniversity Hospital Cologne · DEUniversity of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposesPhysical activity is supposed to decrease mortality of colorectal cancer (CRC) and is suggested to reduce side-effects of the disease and its treatment. However, the knowledge about the influence of exercise interventions on patients suffering from CRC and metastasized CRC (mCRC) is still sparse. One frequently observed side effect in mCRC is chemotherapy-induced peripheral neuropathy (CIPN). This randomized controlled trial investigated the influence of a supervised exercise program on CIPN in mCRC.

methodsThirty patients (stage IV) undergoing outpatient palliative treatment including a median of 23.5 chemotherapy cycles of various regimens were randomly assigned to an intervention or control group (IG, n = 17; CG, n = 13). The IG participated in an eight-week supervised exercise program, including endurance, resistance and balance training (2×/week for 60 min) whereas the CG received written standard recommendations to obtain physical fitness. CIPN was assessed using the FACT/GOG-NTX questionnaire. Moreover, endurance capacity (6MWT), strength (h1RM) and balance (GGT-Reha) were evaluated before (t

resultsNeuropathic symptoms remained stable in the IG over time, while CIPN significantly worsened in the CG from t

conclusionsThis is the first investigation showing positive effects of a multimodal exercise program on CIPN, balance and strength on mCRC patients in a palliative setting, thereby consequently increasing patients` quality of life. The results support earlier findings stating a positive influence of balance exercise on CIPN.

Indexed as

AgedAged, 80 and overColorectal NeoplasmsExerciseExercise TherapyFemaleHumansLongitudinal StudiesMaleMiddle AgedPeripheral Nervous System DiseasesQuality of LifeAdvanced colorectal cancerBalanceCIPNExercise

Identifiers

PMID28963591
OpenAlexW2758301844

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.