Evidence map›Paper›PMID 28963581›Full record

ArticleClinical research in cardiology : official journal of the German Cardiac Society2018

Pacemaker implantation after TAVI: predictors of AV block persistence.

Luise Gaede, Won-Keun Kim, Christoph Liebetrau, Oliver Dörr, Johannes Sperzel, Johannes Blumenstein, Alexander Berkowitsch, Thomas Walther, Christian Hamm, Albrecht Elsässer and 2 more

Registry-linked trialAbstract read
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In one paragraph

Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04128384 (Changes in Infranodal Conduction Times and New Onset Left Bundle Branch Block), which is not on this map. Cited by 37 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 2 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04128384 naunknown statusnot on this map

Changes in Infranodal Conduction Times and New Onset Left Bundle Branch Block: Possible Predictors for High-grade AV Block Following Transcatheter Aortic Valve Replacement

TypeinterventionalSponsorUniversity Hospital, SaarlandRan2018 to 2023Enrolled200ConditionsSevere Aortic Valve Stenosis, High-degree AV Block, Left Bundle-Branch BlockArmsLimited electrophysiologic study including measurements of HV- and AH-intervals pre- and post-TAVR
3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 2 syntheses or guidelines pooled it, 85 citations in OpenAlex.

  1. Pooled it
  2. Transcatheter aortic valve replacement for pure aortic valve regurgitation: "on-label" versus "off-label" use of TAVR devices.Clinical research in cardiology : official journal of the German Cardiac Society · 2019
    Pooled it
  3. Article
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  5. [Left bundle branch pacing in a patient with decreased cardiac function after transcatheter aortic valve replacement].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2025
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  12. 2021 ESC Guidelines on cardiac pacing and cardiac resynchronization therapy.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2022
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  14. Predictors of conduction recovery after permanent pacemaker implantation following transcatheter aortic valve replacement.Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Luise GaedeDepartment of Cardiology, St.-Johannes-Hospital, Medizinische Klinik I, Johannesstraße 9-13, 44137, Dortmund, Germany.
Won-Keun KimDepartment of Cardiology, Kerckhoff Heart and Thorax Center, Bad Nauheim, Germany.
Christoph LiebetrauDepartment of Cardiology, Kerckhoff Heart and Thorax Center, Bad Nauheim, Germany.
Oliver DörrDepartment of Cardiology and Angiology, Medical Clinic I, University of Giessen, Giessen, Germany.
Johannes SperzelDepartment of Cardiology, Kerckhoff Heart and Thorax Center, Bad Nauheim, Germany.
Johannes BlumensteinDepartment of Cardiology, St.-Johannes-Hospital, Medizinische Klinik I, Johannesstraße 9-13, 44137, Dortmund, Germany.
Alexander BerkowitschDepartment of Cardiology, Kerckhoff Heart and Thorax Center, Bad Nauheim, Germany.
Thomas WaltherDepartment of Cardiac Surgery, Kerckhoff Heart and Thorax Center, Bad Nauheim, Germany.
Christian HammDepartment of Cardiology, Kerckhoff Heart and Thorax Center, Bad Nauheim, Germany.
Albrecht ElsässerDepartment of Cardiology, University of Oldenburg, Oldenburg, Germany.
Holger NefDepartment of Cardiology and Angiology, Medical Clinic I, University of Giessen, Giessen, Germany.
Helge MöllmannDepartment of Cardiology, St.-Johannes-Hospital, Medizinische Klinik I, Johannesstraße 9-13, 44137, Dortmund, Germany. moellmann@me.com.
Kerckhoff Klinik · DESt.-Johannes-Hospital Dortmund · DEUniversitätsklinikum Gießen und Marburg · DECarl von Ossietzky Universität Oldenburg · DEUniversity of Giessen · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimsApproximately every fifth patient undergoing transcatheter aortic valve implantation (TAVI) requires a permanent pacemaker (PPM) after the procedure. The aim of this study was to analyse predictors of atrioventricular block III° (AVBIII) persistence with concurrent PPM dependency after TAVI. METHODS AND

resultsBetween 2010 and 2015 a total of 1198 patients underwent TAVI at the Kerckhoff Heart and Thorax Center, Germany. After exclusion of patients with prior PPM (n = 173) 14.7% (n = 176) of the patients underwent PPM implantation after the procedure. Independent predictors of PPM implantation were pre-existing right bundle branch block (RBBB, p < 0.001) and implantation of a CoreValve prosthesis (p < 0.001). A subgroup of patients with a newly implanted PPM (n = 102) were followed-up for a median of 73 (IQR 62-85) days. The leading indication for PPM implantation was AVBIII in 74.5% (76/102). Of these patients only 22.4% (17/76) had persistent AVBIII at follow-up. Predictors of AVBIII persistence were prior RBBB (p = 0.04), postdilatation (p = 0.006) and higher mean aortic valve gradient prior to implantation (p = 0.013). PPMs were implanted earlier in patients with persisting AVBIII [1 day (IQR0-2.5) vs. 4 days (IQR2-7); p < 0.001]. Early PPM implantation after TAVI was the only independent predictor of persistent AVBIII [OR 1.36 (95% 1.05-1.75); p = 0.02].

conclusionThe long-term persistence of AVBIII is generally low after TAVI. Therefore, it may be wise to postpone the indication for PPM implantation for a couple of days. The only predictors of a lack of recovery of the AVB are prior RBBB, higher mean aortic valve gradients and postdilatation of the prosthesis.

Indexed as

Cardiac Pacing, ArtificialPacemaker, ArtificialAgedAged, 80 and overAortic ValveAortic Valve StenosisAtrioventricular BlockFemaleGermanyHumansMaleMultivariate AnalysisOdds RatioPredictive Value of TestsProportional Hazards ModelsRisk FactorsAVBIIIAV blockPacemakerPPMTAVITAVR

Identifiers

PMID28963581
OpenAlexW2758829266

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.