Evidence map›Paper›PMID 28963570›Full record

ReviewJournal of molecular medicine (Berlin, Germany)2017

Interplay between circadian clock and viral infection.

Xiaodong Zhuang, Srinivasa Bhargav Rambhatla, Alvina G Lai, Jane A McKeating

Abstract readReview
In one paragraph

Review in Journal of molecular medicine (Berlin, Germany), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed.

  1. Trial
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  12. Hepatitis B and circadian rhythm of the liver.World journal of gastroenterology · 2022
    Review
  13. Article
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  15. Review
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  19. Circadian Effects of Drug Responses.Annual review of biomedical engineering · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Xiaodong ZhuangNuffield Department of Medicine, University of Oxford, Oxford, UK. xiaodong.zhuang@ndm.ox.ac.uk.ORCID 0000-0002-6870-9003
Srinivasa Bhargav RambhatlaInstitute for Immunology and Immunotherapy, University of Birmingham, Birmingham, UK.
Alvina G LaiNuffield Department of Medicine, University of Oxford, Oxford, UK.
Jane A McKeatingNuffield Department of Medicine, University of Oxford, Oxford, UK.

Funding

Medical Research Council G0801976Medical Research Council G1100247Medical Research Council MC_PC_16056Medical Research Council MR/K01532X/1Wellcome Trust
6 · The paper itself

Abstract

The circadian clock underpins most physiological conditions and provides a temporal dimension to our understanding of body and tissue homeostasis. Disruptions of circadian rhythms have been associated with many diseases, including metabolic disorders and cancer. Recent literature highlights a role for the circadian clock to regulate innate and adaptive immune functions that may prime the host response to infectious organisms. Viruses are obligate parasites that rely on host cell synthesis machinery for their own replication, survival and dissemination. Here, we review key findings on how circadian rhythms impact viral infection and how viruses modulate molecular clocks to facilitate their own replication. This emerging area of viral-clock biology research provides a fertile ground for discovering novel anti-viral targets and optimizing immune-based therapies.

Indexed as

AnimalsCircadian ClocksHost-Pathogen InteractionsHumansImmunityVirus DiseasesCircadian rhythmsInfectious diseaseViruses

Identifiers

PMID28963570
PMCPMC5684296

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.