ArticleScientific reports2017
Modeling the Kinetics of Integrin Receptor Binding to Hepatic Extracellular Matrix Proteins.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Challenges ofFrontiers in cell and developmental biology · 2025Review
- Identification of glycolysis-related gene signatures for prognosis and therapeutic targeting in idiopathic pulmonary fibrosis.Frontiers in pharmacology · 2025Article
- Hepatic Extracellular Matrix and Its Role in the Regulation of Liver Phenotype.Seminars in liver disease · 2024Review
- Mechanical homeostasis imbalance in hepatic stellate cells activation and hepatic fibrosis.Frontiers in molecular biosciences · 2023Review
- Self-supervised classification of subcellular morphometric phenotypes reveals extracellular matrix-specific morphological responses.Scientific reports · 2022Article
- Cutaneous Regeneration Mechanism of β-Sheet Silk Fibroin in a Rat Burn Wound Healing Model.Polymers · 2021Article
- Article
- Modeling of tumor response to macrophage and T lymphocyte interactions in the liver metastatic microenvironment.Cancer immunology, immunotherapy : CII · 2021Article
- Substrate Stiffness Mediates Formation of Novel Cytoskeletal Structures in Fibroblasts during Cell-Microspheres Interaction.International journal of molecular sciences · 2021Article
- Impact of tumor-parenchyma biomechanics on liver metastatic progression: a multi-model approach.Scientific reports · 2021Article
- Win, Lose, or Tie: Mathematical Modeling of Ligand Competition at the Cell-Extracellular Matrix Interface.Frontiers in bioengineering and biotechnology · 2021Article
- Towards understanding the messengers of extracellular space: Computational models of outside-in integrin reaction networks.Computational and structural biotechnology journal · 2021Review
- The liver matrisome - looking beyond collagens.JHEP reports : innovation in hepatology · 2020Review
- A Multiscale Model to Predict Neuronal Cell Deformation with Varying Extracellular Matrix Stiffness and Topography.Cellular and molecular bioengineering · 2020Article
- Modeling of Nanotherapy Response as a Function of the Tumor Microenvironment: Focus on Liver Metastasis.Frontiers in bioengineering and biotechnology · 2020Review
- Computational/experimental evaluation of liver metastasis post hepatic injury: interactions with macrophages and transitional ECM.Scientific reports · 2019Article
- The extracellular matrix as a key regulator of intracellular signalling networks.British journal of pharmacology · 2019Review
- Evaluation of hepatic integrin αvβ3 expression in non-alcoholic steatohepatitis (NASH) model mouse byEJNMMI research · 2018Article
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
The composition of the extracellular matrix (ECM) proteins and the expression of their cognate receptors dictate cell behavior and dynamics. In particular, the interactions of ECM proteins with integrin receptors are key mediators of these cellular processes, playing a crucial role in the progression of several diseases of the liver, including inflammation, fibrosis/cirrhosis and cancer. This study establishes a modeling approach combining computation and experiments to evaluate the kinetics of integrin receptor binding to hepatic ECM proteins. ECM ligand concentration was derived from LC-MS/MS quantification of the hepatic ECM from mice exposed to chronic carbon tetrachloride (CCl
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