ArticleScientific reports2017
Somatic Arc protein expression in hippocampal granule cells is increased in response to environmental change but independent of task-specific learning.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Hippocampal engrams configure prefrontal context representations to guide flexible decisions.bioRxiv : the preprint server for biology · 2026Article
- Sex related differences in cognitive deficits: Disrupted Arc/Arg3.1 signaling in an HIV model.Neuroscience letters · 2025Article
- Spatially resolved transcriptomic signatures of hippocampal subregions andFrontiers in molecular neuroscience · 2024Article
- Article
- Visualizing Arc protein dynamics and localization in the mammalian brain using AAV-mediatedFrontiers in molecular neuroscience · 2023Article
- The impact of Semaphorin 4C/Plexin-B2 signaling on fear memory via remodeling of neuronal and synaptic morphology.Molecular psychiatry · 2021Article
- Protocol for Short- and Longer-term Spatial Learning and Memory in Mice.Frontiers in behavioral neuroscience · 2017Article
- Multi-session delivery of synchronous rTMS and sensory stimulation induces long-term plasticity.Brain stimulationArticle
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
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Abstract
Activated neurons express immediate-early genes, such as Arc. Expression of Arc in the hippocampal granule cell layer, an area crucial for spatial learning and memory, is increased during acquisition of spatial learning; however, it is unclear whether this effect is related to the task-specific learning process or to nonspecific aspects of the testing procedure (e.g. exposure to the testing apparatus and exploration of the environment). Herein, we show that Arc-positive cells numbers are increased to the same extent in the granule cell layer after both acquisition of a single spatial learning event in the active place avoidance task and exploration of the testing environment, as compared to naïve (i.e. caged) mice. Repeated exposure the testing apparatus and environment did not reduce Arc expression. Furthermore, Arc expression did not correlate with performance in both adult and aged animals, suggesting that exploration of the testing environment, rather than the specific acquisition of the active place avoidance task, induces Arc expression in the dentate granule cell layer. These findings thus suggest that Arc is an experience-induced immediate-early gene.
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