ArticleScientific reports2017
A dietary carotenoid reduces immunopathology and enhances longevity through an immune depressive effect in an insect model.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 75 citations in OpenAlex.
- Antioxidants, oxidative stress and reactive oxygen species in insects exposed to heat.Current research in insect science · 2025Review
- Carotenoid-based immune response in sea cucumbers relies on newly identified coelomocytes-the carotenocytes.Frontiers in immunology · 2025Article
- Infection risk by oral contamination does not induce immune priming in the mealworm beetle (Frontiers in immunology · 2024Article
- Reservoir host immunology and life history shape virulence evolution in zoonotic viruses.PLoS biology · 2023Article
- Astaxanthin as a King of Ketocarotenoids: Structure, Synthesis, Accumulation, Bioavailability and Antioxidant Properties.Marine drugs · 2023Review
- Developing Strategies to Help Bee Colony Resilience in Changing Environments.Animals : an open access journal from MDPI · 2022Review
- Senescence of the immune defences and reproductive trade-offs in females of the mealworm beetle, Tenebrio molitor.Scientific reports · 2022Article
- Insect Models in Nutrition Research.Biomolecules · 2022Review
- The impact of life stage and pigment source on the evolution of novel warning signal traits.Evolution; international journal of organic evolution · 2022Article
- Review
- Testing Virulence of Different Species of Insect Associated Fungi against Yellow Mealworm (Coleoptera: Tenebrionidae) and Their Potential Growth Stimulation to Maize.Plants (Basel, Switzerland) · 2021Article
- Potential of natural astaxanthin in alleviating the risk of cytokine storm in COVID-19.Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie · 2020Review
- Astaxanthin and its Effects in Inflammatory Responses and Inflammation-Associated Diseases: Recent Advances and Future Directions.Molecules (Basel, Switzerland) · 2020Review
- Terpenoids as Potential Geroprotectors.Antioxidants (Basel, Switzerland) · 2020Review
- Growth Performance and Nutrient Composition of Mealworms (Foods (Basel, Switzerland) · 2020Article
- Structures of Astaxanthin and Their Consequences for Therapeutic Application.International journal of food science · 2020Review
- Origin of the natural variation in the storage of dietary carotenoids in freshwater amphipod crustaceans.PloS one · 2020Article
- Mitochondrial Function, Mobility and Lifespan Are Improved inMarine drugs · 2019Article
- Immune Defenses of a Beneficial Pest: The Mealworm Beetle,Frontiers in physiology · 2019Review
- Roles of Carotenoids in Invertebrate Immunology.Frontiers in immunology · 2019Review
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immunopathology corresponds to self-damage of the inflammatory response, resulting from oxidizing molecules produced when the immune system is activated. Immunopathology often contributes to age-related diseases and is believed to accelerate ageing. Prevention of immunopathology relies on endogenous antioxidant enzymes and the consumption of dietary antioxidants, including carotenoids such as astaxanthin. Astaxanthin currently raises considerable interest as a powerful antioxidant and for its potential in alleviating age-related diseases. Current in vitro and short-term in vivo studies provide promising results about immune-stimulating and antioxidant properties of astaxanthin. However, to what extent dietary supplementation with astaxanthin can prevent long-term adverse effects of immunopathology on longevity is unknown so far. Here, using the mealworm beetle, Tenebrio molitor, as biological model we tested the effect of lifetime dietary supplementation with astaxanthin on longevity when exposed to early life inflammation. While supplementation with astaxanthin was found to lessen immunopathology cost on larval survival and insect longevity, it was also found to reduce immunity, growth rate and the survival of non immune-challenged larvae. This study therefore reveals that astaxanthin prevents immunopathology through an immune depressive effect and can have adverse consequences on growth.
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