Evidence map›Paper›PMID 28963499›Full record

ArticleScientific reports2017

Apontic directly activates hedgehog and cyclin E for proper organ growth and patterning.

Xian-Feng Wang, Yang Shen, Qian Cheng, Chong-Lei Fu, Zi-Zhang Zhou, Susumu Hirose, Qing-Xin Liu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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  3. Review
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  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Xian-Feng WangLaboratory of Developmental Genetics, Shandong Agricultural University, Tai'an, Shandong, 271018, China.ORCID 0000-0001-7207-7865
Yang ShenLaboratory of Developmental Genetics, Shandong Agricultural University, Tai'an, Shandong, 271018, China.
Qian ChengLaboratory of Developmental Genetics, Shandong Agricultural University, Tai'an, Shandong, 271018, China.
Chong-Lei FuLaboratory of Developmental Genetics, Shandong Agricultural University, Tai'an, Shandong, 271018, China.
Zi-Zhang ZhouLaboratory of Developmental Genetics, Shandong Agricultural University, Tai'an, Shandong, 271018, China.
Susumu HiroseDepartment of Developmental Genetics, National Institute of Genetics, Mishima, Shizuoka, 411-8540, Japan. shirose@nig.ac.jp.
Qing-Xin LiuLaboratory of Developmental Genetics, Shandong Agricultural University, Tai'an, Shandong, 271018, China. liuqingxin@sdau.edu.cn.
Shandong Agricultural University · CNNational Institute of Genetics · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hedgehog (Hh) signaling pathway and Cyclin E are key players in cell proliferation and organ development. Hyperactivation of hh and cyclin E has been linked to several types of cancer. However, coordination of the expression of hh and cyclin E was not well understood. Here we show that an evolutionarily conserved transcription factor Apontic (Apt) directly activates hh and cyclin E through its binding site in the promoter regions of hh and cyclin E. This Apt-dependent proper expression of hh and cyclin E is required for cell proliferation and development of the Drosophila wing. Furthermore, Fibrinogen silencer-binding protein (FSBP), a mammalian homolog of Apt, also positively regulates Sonic hh (Shh), Desert hh (Dhh), Cyclin E1 (CCNE1) and Cyclin E2 (CCNE2) in cultured human cells, suggesting evolutionary conservation of the mechanism. Apt-mediated expression of hh and cyclin E can direct proliferation of Hh-expressing cells and simultaneous growth, patterning and differentiation of Hh-recipient cells. The discovery of the simultaneous expression of Hh and principal cell-cycle regulator Cyclin E by Apt implicates insight into the mechanism by which deregulated hh and cyclin E promotes tumor formation.

Indexed as

AnimalsBase SequenceBinding SitesBiological EvolutionBody PatterningCarrier ProteinsCell ProliferationCell Transformation, NeoplasticConserved SequenceCyclin ECyclinsDNA-Binding ProteinsDrosophila melanogasterDrosophila ProteinsFemaleFetal Proteinsapt protein, DrosophilaCarrier ProteinsCCNE1 protein, humanCCNE2 protein, humanCycE protein, DrosophilaCyclin ECyclinsDHH protein, humanDNA-Binding ProteinsDrosophila ProteinsFetal Proteinsfetal steroid-binding protein, humanHedgehog Proteinshh protein, DrosophilaIntracellular Signaling Peptides and ProteinsOncogene ProteinsSHH protein, humanTranscription Factors

Identifiers

PMID28963499
PMCPMC5622130
OpenAlexW2757208298

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.