Evidence map›Paper›PMID 28963481›Full record

ArticleNature communications2017

Synthetic microparticles conjugated with VEGF

Sezin Aday, Janet Zoldan, Marie Besnier, Laura Carreto, Jaimy Saif, Rui Fernandes, Tiago Santos, Liliana Bernardino, Robert Langer, Costanza Emanueli and 1 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 43 citations in OpenAlex.

  1. [Research progress of different types of stem cells in treatment of ischemic stroke].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2021
    Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Matrix Vesicles as a Therapeutic Target for Vascular Calcification.Frontiers in cell and developmental biology · 2022
    Review
  10. Article
  11. Design Challenges in Polymeric Scaffolds for Tissue Engineering.Frontiers in bioengineering and biotechnology · 2021
    Review
  12. Materials to Promote Recovery After Stroke.Current opinion in biomedical engineering · 2020
    Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Building Blood Vessels with Vascular Progenitor Cells.Trends in molecular medicine · 2018
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 3 countries.

Sezin AdayCNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517, Coimbra, Portugal.
Janet ZoldanDepartment of Biomedical Engineering, Cockrell School of Engineering, The University of Texas at Austin, Austin, TX, 78712, USA.
Marie BesnierBristol Heart Institute, School of Clinical Sciences, University of Bristol, Bristol, BS2 8HW, UK.
Laura CarretoUniversity of Aveiro, 3810-193, Aveiro, Portugal.
Jaimy SaifBristol Heart Institute, School of Clinical Sciences, University of Bristol, Bristol, BS2 8HW, UK.
Rui FernandesHEMS-Histology and Electron Microscopy Service, IBMC/I3S, Universidade do Porto, 4200-135, Porto, Portugal.
Tiago SantosHealth Sciences Research Centre, Faculty of Health Sciences, University of Beira Interior, 6201-506, Covilhã, Portugal.
Liliana BernardinoHealth Sciences Research Centre, Faculty of Health Sciences, University of Beira Interior, 6201-506, Covilhã, Portugal.
Robert LangerDepartment of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, 02139, USA.
Costanza EmanueliBristol Heart Institute, School of Clinical Sciences, University of Bristol, Bristol, BS2 8HW, UK. Costanza.Emanueli@bristol.ac.uk.
Lino FerreiraCNC-Center for Neuroscience and Cell Biology, University of Coimbra, 3004-517, Coimbra, Portugal. lino@uc-biotech.pt.
University of Bristol · GBMassachusetts Institute of Technology · USUniversity of Beira Interior · PTThe University of Texas at Austin · USUniversidade do Porto · PTUniversity of Aveiro · PTUniversity of Coimbra · PT

Funding

British Heart Foundation RG/15/5/31446
6 · The paper itself

Abstract

Several cell-based therapies are under pre-clinical and clinical evaluation for the treatment of ischemic diseases. Poor survival and vascular engraftment rates of transplanted cells force them to work mainly via time-limited paracrine actions. Although several approaches, including the use of soluble vascular endothelial growth factor (sVEGF)-VEGF

Indexed as

Cell SurvivalCell- and Tissue-Based TherapyCell-Derived MicroparticlesCyclin-Dependent Kinase Inhibitor p21DNA-Binding ProteinsEndothelial Progenitor CellsFetal BloodGene Expression RegulationHumansHuman Umbilical Vein Endothelial CellsIschemiaMicroRNAsNeovascularization, PhysiologicPhosphorylationProto-Oncogene Proteins c-aktVascular Endothelial Growth Factor ACDKN1A protein, humanCdkn1a protein, mouseCyclin-Dependent Kinase Inhibitor p21DNA-Binding ProteinsKDR protein, humanKdr protein, mouseMicroRNAsMIRN17 microRNA, humanMirn17 microRNA, mouseProto-Oncogene Proteins c-aktVascular Endothelial Growth Factor Avascular endothelial growth factor A, mouseVascular Endothelial Growth Factor Receptor-2VEGFA protein, humanZNF652 protein, human

Identifiers

PMID28963481
PMCPMC5622042
OpenAlexW2759504685

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.