ArticleScientific reports2017
Comparative Transcriptome Analysis of Mink (Neovison vison) Skin Reveals the Key Genes Involved in the Melanogenesis of Black and White Coat Colour.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 46 citations in OpenAlex.
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- Integrative Transcriptomic and Proteomic Profiling Identifies PMEL as a Critical Regulator of Melanogenesis in Rex Rabbits.Animals : an open access journal from MDPI · 2025Article
- Ssc-mir-221-3p regulates melanin production in Xiang pigs melanocytes by targeting the TYRP1 gene.BMC genomics · 2023Article
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- Genome-wide detection of copy number variation in American mink using whole-genome sequencing.BMC genomics · 2022Article
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- Genetic and phenotypic parameters for feed efficiency and component traits in American mink.Journal of animal science · 2022Article
- Genetic and phenotypic parameters for body weights, harvest length, and growth curve parameters in American mink.Journal of animal science · 2021Article
- High Genetic Diversity of an Invasive Alien Species: Comparison between Fur-Farmed and Feral American Mink (Animals : an open access journal from MDPI · 2021Article
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- Five genetic variants explain over 70% of hair coat pheomelanin intensity variation in purebred and mixed breed domestic dogs.PloS one · 2021Article
- Transcriptome-based selection and validation of optimal house-keeping genes for skin research in goats (Capra hircus).BMC genomics · 2020Article
- Transcriptome Comparison Reveals Key Components of Nuptial Plumage Coloration in Crested Ibis.Biomolecules · 2020Article
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- KIT is involved in melanocyte proliferation, apoptosis and melanogenesis in the Rex Rabbit.PeerJ · 2020Article
- Identification of copy number variations using high density whole-genome SNP markers in Chinese Dongxiang spotted pigs.Asian-Australasian journal of animal sciences · 2019Article
- Variation in pigmentation gene expression is associated with distinct aposematic color morphs in the poison frog Dendrobates auratus.BMC evolutionary biology · 2019Article
- Article
- Transcriptome profiling analysis reveals key genes of different coat color in sheep skin.PeerJ · 2019Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Farmed mink (Neovison vison) is one of the most important fur-bearing species worldwide, and coat colour is a crucial qualitative characteristic that contributes to the economic value of the fur. To identify additional genes that may play important roles in coat colour regulation, Illumina/Solexa high-throughput sequencing technology was used to catalogue the global gene expression profiles in mink skin with two different coat colours (black and white). RNA-seq analysis indicated that a total of 12,557 genes were differentially expressed in black versus white minks, with 3,530 genes up-regulated and 9,027 genes down-regulated in black minks. Significant differences were not observed in the expression of MC1R and TYR between the two different coat colours, and the expression of ASIP was not detected in the mink skin of either coat colour. The expression levels of KITLG, LEF1, DCT, TYRP1, PMEL, Myo5a, Rab27a and SLC7A11 were validated by qRT-PCR, and the results were consistent with RNA-seq analysis. This study provides several candidate genes that may be associated with the development of two coat colours in mink skin. These results will expand our understanding of the complex molecular mechanisms underlying skin physiology and melanogenesis in mink and will provide a foundation for future studies.
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