ArticleScientific reports2017
Zfp296 negatively regulates H3K9 methylation in embryonic development as a component of heterochromatin.
Article in Scientific reports, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 24 citations in OpenAlex.
- Targeting PURPL RNA enabled rejuvenation of senescence cells via epigenetic reprogramming.Journal of translational medicine · 2025Article
- The Multifaceted Roles of Zinc Finger Proteins in Pluripotency and Reprogramming.International journal of molecular sciences · 2025Review
- Specific human gene expression in response to infection is an effective marker for diagnosis of latent and active tuberculosis.Scientific reports · 2024Article
- Suppression of host gene expression is associated with latent TB infection: a possible diagnostic biomarker.Scientific reports · 2024Article
- Analysis and Validation of Critical Signatures and Immune Cell Infiltration Characteristics in Doxorubicin-Induced Cardiotoxicity by Integrating Bioinformatics and Machine Learning.Journal of inflammation research · 2024Article
- Acute irradiation induces a senescence-like chromatin structure in mammalian oocytes.Communications biology · 2023Article
- Zfp296 knockout enhances chromatin accessibility and induces a unique state of pluripotency in embryonic stem cells.Communications biology · 2023Article
- The Novel Role ofInternational journal of molecular sciences · 2023Article
- Article
- The Nucleosome Remodelling and Deacetylation complex suppresses transcriptional noise during lineage commitment.The EMBO journal · 2019Article
- Single cell transcriptome analysis of human, marmoset and mouse embryos reveals common and divergent features of preimplantation development.Development (Cambridge, England) · 2018Article
- NuRD-interacting protein ZFP296 regulates genome-wide NuRD localization and differentiation of mouse embryonic stem cells.Nature communications · 2018Article
- Tracing the transitions from pluripotency to germ cell fate with CRISPR screening.Nature communications · 2018Article
- Integrated analysis of single-cell embryo data yields a unified transcriptome signature for the human pre-implantation epiblast.Development (Cambridge, England) · 2018Article
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Cys2/His2-type zinc finger protein Zfp296 has been implicated in stem cell pluripotency and tumor pathogenesis. However, its mechanisms remain elusive. Here, we demonstrated that a Zfp296 deficiency in mice impairs germ-cell development and embryonic growth. Zfp296 was intracellularly localized to heterochromatin in embryos. A GST-Zfp296 pull-down experiment using ES cell nuclear extract followed by LC-MS/MS showed that Zfp296 interacts with component proteins of heterochromatin (such as HP1, Dnmt1, Dnmt3b, and ATRX) and the NuRD complex. We focused on H3K9 methylation as a hallmark of heterochromatin, and found that Zfp296 overexpression in cultured cells reduces the Suv39h1-mediated H3K9 methylation. Consistent with this finding, in Zfp296
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