Evidence map›Paper›PMID 28963316›Full record

Observational studyBMJ open2017

Canada-DONATE study protocol: a prospective national observational study of the medical management of deceased organ donors.

Frederick D'Aragon, Sonny Dhanani, Francois Lamontagne, Deborah J Cook, Karen Burns, Aemal Akhtar, Michaël Chassé, Anne-Julie Frenette, Sean Keenan, Jean-Francois Lize and 15 more

Registry-linked trialAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03114436 (Canada-DONATE), which is not on this map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03114436 completednot on this map

Canada-DONATE: National Observational Study of Clinical Practices in Deceased Organ Donation

TypeobservationalSponsorMcMaster UniversityRan2016 to 2018Enrolled622ConditionsDeceased Organ Donation, Critical Illness, TransplantationArmsObservational Data Collection
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors.

Frederick D'AragonDepartment of Anesthesiology, Universite de Sherbrooke, Sherbrooke, Quebec, Canada.
Sonny DhananiDivision of Critical Care, Department of Pediatrics, Children's Hospital of Eastern Ontario, University of Ottawa, Ottawa, Ontario, Canada.
Francois LamontagneCentre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada.
Deborah J CookDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Karen BurnsInterdepartmental Division of Critical Care, University of Toronto, Toronto, Ontario, Canada.
Aemal AkhtarDepartment of Health Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.
Michaël ChasséDepartment of Medicine (Critical Care), Centre Hospitalier de l'Universite de Montreal, Montreal, Quebec, Canada.
Anne-Julie FrenettePharmacy Faculty, Universite de Montreal, Montreal, Quebec, Canada.
Sean KeenanDepartment of Critical Care, Royal Columbian Hospital, New Westminster, British Columbia, Canada.
Jean-Francois LizeDepartment of Medicine (Critical Care), Centre Hospitalier de l'Universite de Montreal, Montreal, Quebec, Canada.
Demetrios J KutsogiannisDepartment of Critical Care Medicine, University of Alberta, Edmonton, Alberta, Canada.
Andreas KramerDepartment of Critical Care Medicine, University of Calgary, Calgary, Alberta, Canada.
Lori E HandDepartment of Health Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.
Erika ArseneauDepartment of Health Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.
Marie-Helene MasseCentre de Recherche du Centre Hospitalier Universitaire de Sherbrooke, Sherbrooke, Quebec, Canada.
Christine RibicDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Ian BallDepartment of Medicine, Western University, London, Ontario, Canada.
Andrew BakerInterdepartmental Division of Critical Care, University of Toronto, Toronto, Ontario, Canada.
Gordon BoydDepartment of Medicine (Neurology), Queen's University, Kingston, Ontario, Canada.
Bram RochwergDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.ORCID http://orcid.org/0000-0002-8293-7061
Andrew HealeyDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Steven HannaDepartment of Health Evidence and Impact, McMaster University, Hamilton, Ontario, Canada.
Gordon H GuyattDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Maureen O MeadeDepartment of Medicine, McMaster University, Hamilton, Ontario, Canada.
Canadian Critical Care Trials Group and the Canadian National Transplant Research Program

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionResearch on the management of deceased organ donors aims to improve the number and quality of transplants and recipient outcomes. In Canada, this research is challenged by regionalisation of donation services within provinces and the geographical, clinical and administrative separation of donation from transplantation services. This study aims to build a national platform for future clinical trials in donor management. Objectives are to engage collaborators at donation hospitals and organ donation organisations (ODOs) across Canada, describe current practices, evaluate the effectiveness of donation-specific interventions and assess the feasibility of future clinical trials. METHODS AND ANALYSIS: This ongoing prospective observational study of the medical management of deceased organ donors will enrol more than 650 consented potential donors from adult intensive care units at 33 hospital sites across Canada, each participating for 12 months. ODOs ensure enrolment of consecutive eligible participants. Research staff record detailed data about participants, therapies, organ assessments, death declaration procedures and adverse clinical exposures from the time of donation consent to organ recovery. ODOs provide reasons that organs are declined, dates and places of transplantation, and recipient age and sex.Descriptive analyses will summarise current practices. Effectiveness analyses will examine donation-specific interventions with respect to the number of transplants, using multilevel regression models to account for clustering by donor, hospitals and ODOs. Feasibility analyses will focus on acceptance of the research consent model; participation of academic and community hospitals as well as ODOs; and accessibility of recipient data. ETHICS AND DISSEMINATION: This study uses a waiver of research consent. Hospitals will receive reports on local practices benchmarked to (1) national practices and (2) national donor management guidelines. We will report findings to donation and transplant collaborators (ie, clinicians, researchers, ODOs) and publish in peer-reviewed journals. TRIAL REGISTRATION NUMBER: NCT03114436.

Indexed as

Intensive Care UnitsCanadaClinical ProtocolsFeasibility StudiesFemaleHumansMaleOrgan TransplantationProcess Assessment, Health CareProspective StudiesRegression AnalysisTime FactorsTissue and Organ ProcurementTissue Donorsbrain deathorgan donationtransplant medicine

Identifiers

PMID28963316
PMCPMC5640087

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.