ArticleBMJ open2017
Thiazide diuretics and the risk of hip fracture after stroke: a population-based propensity-matched cohort study using Taiwan's National Health Insurance Research Database.
Article in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 2 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 2 syntheses or guidelines pooled it, 15 citations in OpenAlex.
- Thiazide Use and Fracture Risk: An updated Bayesian Meta-Analysis.Scientific reports · 2019Pooled it
- Thiazide Diuretics and the Incidence of Osteoporotic Fracture: A Systematic Review and Meta-Analysis of Cohort Studies.Frontiers in pharmacology · 2019Pooled it
- A longitudinal dataset of hypertensive osteoporotic fracture patients: treatments and long-term outcomes.Scientific data · 2026Article
- The impact of Renin-Angiotensin System Inhibitors on bone fracture risk: a nationwide nested case-control study.BMC musculoskeletal disorders · 2024Article
- Association of Thiazide Use in Patients with Hypertension with Overall Fracture Risk: A Population-Based Cohort Study.Journal of clinical medicine · 2022Article
- Ultrasound-Guided Femoral Nerve Block in Geriatric Patients with Hip Fracture in the Emergency Department.Journal of clinical medicine · 2022Article
- Hysterectomy associated with de novo lower urinary tract symptoms in a Taiwanese population: a nationwide, population-based study.International urogynecology journal · 2019Article
- Association between diuretic use and the risk of vertebral fracture after stroke: a population-based retrospective cohort study.BMC musculoskeletal disorders · 2019Article
- Association between benzodiazepine use and risks of chronic-onset poststroke pneumonia: a population-based cohort study.BMJ open · 2019Article
- Pelvic organ prolapse surgery following hysterectomy with benign indication: a national cohort study in Taiwan.International urogynecology journal · 2018Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study aimed to investigate the association between thiazide use and the risk of hip fracture after stroke.
settingA population-based, propensity-matched cohort study was conducted on the basis of Taiwan's National Health Insurance Research Database.
participantsPatients with newly diagnosed ischaemic stroke between 2000 and 2011 were included. After propensity score matching, 7470 patients were included, of whom 3735 received thiazides and 3735 did not. OUTCOME MEASURES: HRs for developing hip fractures within 2 years after stroke were calculated using Cox proportional hazards regression model with adjustments for sociodemographic and coexisting medical conditions.
resultsOverall, patients using thiazides after stroke had a lower risk of hip fracture than those not using thiazides (8.5 vs 13.9 per 1000 person-years, adjusted HR=0.64, 95% CI 0.46 to 0.89, p=0.007). Further sensitivity analysis based on the duration of thiazide use revealed that the risk of hip fracture tended to decrease as the duration of exposure of thiazides increased. However, the effect was significant only in patients with long-term use of thiazides (using thiazides for >365 days within 2 years after stroke), with a 59% reduction in the risk of hip fracture when compared with patients not using thiazide (adjusted HR=0.41, 95% CI 0.22 to 0.79, p=0.008).
conclusionsThe long-term use of thiazides is associated with a decreased risk of hip fracture after stroke.
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