Observational studyBMJ open2017
Adiposity measures and arterial stiffness in primary care: the MARK prospective observational study.
Observational study in BMJ open, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01428934 (Improving Intermediate Risk Management. MARK Study), which is not on this map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Improving Intermediate Risk Management. MARK Study
Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Determinants of Cardio-Ankle Vascular Index and Heart-Thigh β Index in the MESA.Hypertension (Dallas, Tex. : 1979) · 2025Article
- CUN-BAE adiposity index prediction of incident type 2 diabetes: the Seguimiento Universidad de Navarra prospective cohort.The journal of nutrition, health & aging · 2025Article
- Periodontitis Is Associated With Arterial Stiffness as Measured by Serial Cardio-Ankle Vascular Index (CAVI): A 10-Year Cohort Study.Journal of clinical periodontology · 2025Article
- Elevated body roundness index increases the risk of cardiovascular disease in Chinese patients with circadian syndrome.Frontiers in endocrinology · 2025Article
- A Population-Based Scoring System to Assess the Impact of Individual Risk Factors on Vascular Health.Aging and disease · 2024Article
- Association between visceral fat mass and arterial stiffness among community-based screening participants.Hypertension research : official journal of the Japanese Society of Hypertension · 2023Article
- Relationship of body mass index and visceral fat area combination with arterial stiffness and cardiovascular risk in cardiovascular disease-free people: NHANES (2011-2018).Endocrine connections · 2023Article
- Review
- Observational
- Does body mass index or waist-hip ratio correlate with arterial stiffness based on brachial-ankle pulse wave velocity in Chinese rural adults with hypertension?BMC cardiovascular disorders · 2021Article
- Increased Adiposity Appraised with CUN-BAE Is Highly Predictive of Incident Hypertension. The SUN Project.Nutrients · 2021Article
- Article
- Relationships of Obesity-Related Indices and Metabolic Syndrome with Subclinical Atherosclerosis in Middle-Aged Untreated Japanese Workers.Journal of atherosclerosis and thrombosis · 2020Article
- Arterial Stiffness and Endothelial Function in Young Obese Patients - Vascular Resistance Matters.Journal of atherosclerosis and thrombosis · 2019Article
- Comparative Assessment of Cutoffs for the Cardio-Ankle Vascular Index and Brachial-Ankle Pulse Wave Velocity in a Nationwide Registry: A Cardiovascular Prognostic Coupling Study.Pulse (Basel, Switzerland) · 2019Article
Corrections and comments
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Authors and funding
12 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe cardiovascular risk of obesity is potentially increased by arterial stiffness.
objectiveTo assess the relationship of adiposity measures with arterial stiffness in Caucasian adults with intermediate cardiovascular risk.
settingSix Spanish health centres.
participantsWe enrolled 2354 adults (age range, 35-74 years; mean age, 61.4±7.7 years, 61.9% male).
methodsThis is a cross-sectional study that analyses data from the baseline visit of the improving interMediAte RisK management (MARK) study. The main outcome variables were body mass index (BMI), waist-to-height ratio (WHtR), Clínica Universidad de Navarra-body adiposity estimation (CUN-BAE) body fat percentage and body roundness index (BRI). Vascular function was assessed by the cardio-ankle vascular index (CAVI) with the VaSera device; brachial-ankle pulse wave velocity (baPWV) was determined using a validated equation.
resultsThe mean adiposity measures were a BMI of 29.2±4.4, WHtR of 0.61±0.07, CUN-BAE of 35.7±1.7 and BRI of 5.8±1.7. The mean stiffness measures were a CAVI of 8.8±1.2 and baPWV of 14.9±2.5. In multiple linear regression analyses, all adiposity measures were negatively associated with CAVI and baPWV (p<0.01 for all) after adjustment for possible factors of confusion. The proportion of CAVI variability via the adiposity measures were 5.5% for BMI, 5.8% for CUN-BAE, 3.8% for WHtR and 3.7% for BRI. These were higher among diabetic, obese, younger (≤62 years) and non-hypertensive subjects who had similar activity and sedentary profiles.
conclusionsAdiposity measures are negatively associated with arterial stiffness measures. The percentage of variation in CAVI explained by its relation to the different measures of adiposity ranges from 5.8% (CUN-BAE) to 3.7% (BRI). In the case of baPWV, it oscillates between 0.7% (CUN-BAE and BMI) and 0.1% (WHtR). TRIAL REGISTRATION NUMBER: NCT01428934.
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