ArticleBMC infectious diseases2017
Laboratory-acquired infections of Salmonella enterica serotype Typhi in South Africa: phenotypic and genotypic analysis of isolates.
Article in BMC infectious diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 53 citations in OpenAlex.
- A case of laboratory-acquired Salmonella Typhi infection due to phage typing in Japan: whole-genome sequencing confirms the source of infection.Access microbiology · 2026Article
- Unravelling the Persistence of the Rare SerovarPathogens (Basel, Switzerland) · 2025Article
- Whole-genome sequencing for surveillance ofAfrican journal of laboratory medicine · 2025Article
- Enteric fever cluster identification in South Africa using genomic surveillance ofMicrobial genomics · 2023Article
- Metagenomics-enabled microbial surveillance.Nature microbiology · 2022Review
- Editorial: Emerging technologies in infectious disease treatment, prevention and control.Frontiers in cellular and infection microbiology · 2022Article
- Zika Virus Infection During Research Vaccine Development: Investigation of the Laboratory-Acquired InfectionFrontiers in cellular and infection microbiology · 2022Review
- Genomic Characterization of Endemic and Ecdemic Non-typhoidalFrontiers in microbiology · 2021Article
- Outbreak ofFoodborne pathogens and disease · 2019Article
- Incidence and Characterization ofFrontiers in microbiology · 2019Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundWorkers in clinical microbiology laboratories are exposed to a variety of pathogenic microorganisms. Salmonella species is among the most commonly reported bacterial causes of laboratory-acquired infections. We report on three cases of laboratory-acquired Salmonella enterica serotype Typhi (Salmonella Typhi) infection which occurred over the period 2012 to 2016 in South Africa.
methodsLaboratory investigation included phenotypic and genotypic characterization of isolates. Phenotypic analysis included standard microbiological identification techniques, serotyping and antimicrobial susceptibility testing. Genotypic analysis included the molecular subtyping methodologies of pulsed-field gel electrophoresis analysis, multilocus sequence typing and whole-genome sequencing (WGS); with WGS data analysis including phylogenetic analysis based upon comparison of single nucleotide polymorphism profiles of isolates.
resultsAll cases of laboratory-acquired infection were most likely the result of lapses in good laboratory practice and laboratory safety. The following critical issues were highlighted. There was misdiagnosis and misreporting of Salmonella Typhi as nontyphoidal Salmonella by a diagnostic laboratory, with associated public health implications. We highlight issues concerning the importance of accurate fluoroquinolone susceptibility testing and interpretation of results according to updated guidelines. We describe potential shortcomings of a single disk susceptibility screening test for fluoroquinolone susceptibility and suggest that confirmatory minimum inhibitory concentration testing should always be performed in cases of invasive Salmonella infections. These antimicrobial susceptibility testing issues resulted in inappropriate ciprofloxacin therapy which may have been responsible for failure in clearance of pathogen from patients. Salmonella Typhi capsular polysaccharide vaccine was not protective in one case, possibly secondarily to a faulty vaccine.
conclusionsMolecular subtyping of isolates proved effective to investigate the genetic relatedness of isolates. Molecular subtyping data interpreted together with epidemiological data allowed us to pinpoint the most likely sources for our cases of laboratory-acquired infection.
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