Evidence map›Paper›PMID 28962574›Full record

ArticleJournal of neuroinflammation2017

α

Raúl Lagos-Cabré, Alvaro Alvarez, Milene Kong, Francesca Burgos-Bravo, Areli Cárdenas, Edgardo Rojas-Mancilla, Ramón Pérez-Nuñez, Rodrigo Herrera-Molina, Fabiola Rojas, Pascal Schneider and 4 more

Open access · goldAbstract read
In one paragraph

Article in Journal of neuroinflammation, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.

0numbers the graph read from it
0cells of the map it votes in
50citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

50 citing papers in PubMed, 78 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Review
  9. Article
  10. The role of astrocytes in depression, its prevention, and treatment by targeting astroglial gliotransmitter release.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  11. Article
  12. Article
  13. Article
  14. P2XBrain, behavior, and immunity · 2023
    Article
  15. Review
  16. Article
  17. Article
  18. Protein kinase B (AKT) upregulation and Thy-1-αJournal of neuroinflammation · 2023
    Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 8 institutions in 3 countries.

Raúl Lagos-CabréCellular Communication Laboratory, Programme of Cellular & Molecular Biology, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, 838-0453, Santiago, Chile.
Alvaro AlvarezCellular Communication Laboratory, Programme of Cellular & Molecular Biology, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, 838-0453, Santiago, Chile.
Milene KongCellular Communication Laboratory, Programme of Cellular & Molecular Biology, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, 838-0453, Santiago, Chile.
Francesca Burgos-BravoCellular Communication Laboratory, Programme of Cellular & Molecular Biology, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, 838-0453, Santiago, Chile.
Areli CárdenasCellular Communication Laboratory, Programme of Cellular & Molecular Biology, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, 838-0453, Santiago, Chile.
Edgardo Rojas-MancillaDepartamento de Ciencias Químicas y Biológicas, Universidad Bernardo O'Higgins, 837-0854, Santiago, Chile.
Ramón Pérez-NuñezCellular Communication Laboratory, Programme of Cellular & Molecular Biology, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, 838-0453, Santiago, Chile.
Rodrigo Herrera-MolinaLeibniz Institute for Neurobiology, Magdeburg, Germany.
Fabiola RojasCenter for Biomedical Research, Faculty of Biological Sciences and Faculty of Medicine, Universidad Andres Bello, Santiago, Chile.
Pascal SchneiderDepartment of Biochemistry, University of Lausanne, 1066, Epalinges, Switzerland.
Mario Herrera-MarschitzProgramme of Molecular & Clinical Pharmacology, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, 838-0453, Santiago, Chile.
Andrew F G QuestCellular Communication Laboratory, Programme of Cellular & Molecular Biology, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, 838-0453, Santiago, Chile.
Brigitte van ZundertCenter for Biomedical Research, Faculty of Biological Sciences and Faculty of Medicine, Universidad Andres Bello, Santiago, Chile.
Lisette LeytonCellular Communication Laboratory, Programme of Cellular & Molecular Biology, Instituto de Ciencias Biomédicas, Facultad de Medicina, Universidad de Chile, 838-0453, Santiago, Chile. lleyton@med.uchile.cl.ORCID http://orcid.org/0000-0001-9690-9638
Advanced Center for Chronic Diseases · CLUniversidad Andrés Bello · CLUniversidad Bernardo O'Higgins · CLUniversity of Chile · CLLeibniz Institute for Neurobiology · DESan Sebastián University · CLUniversidad de Antofagasta · CLUniversity of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundNeuroinflammation involves cytokine release, astrocyte reactivity and migration. Neuronal Thy-1 promotes DITNC1 astrocyte migration by engaging α

methodsWild-type rat astrocytes (TNF-activated) or from human SOD1

resultsThy-1 induced astrocyte migration only after TNF priming. Increased expression of α

conclusionsTherefore, inflammation induces expression of α

Indexed as

AnimalsAnimals, Genetically ModifiedAnimals, NewbornAstrocytesCell MovementCells, CulturedConnexinsDisease Models, AnimalGene Expression RegulationHumansIntegrin alphaVbeta3MiceNerve Tissue ProteinsNeurodegenerative DiseasesRatsReceptors, Purinergic P2ConnexinsIntegrin alphaVbeta3Nerve Tissue ProteinsPanx1 protein, mousepurinergic P2X8 receptorReceptors, Purinergic P2SOD1 G93A proteinSuperoxide DismutaseThy-1 AntigensTumor Necrosis Factor-alphaAmyotrophic lateral sclerosisCell migrationInflammationIntegrinsReactive astrocytes

Identifiers

PMID28962574
PMCPMC5622429
OpenAlexW2758699621

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.