Evidence map›Paper›PMID 28962460›Full record

ArticleToxicology reports2015

Inhibitory actions by ibandronate sodium, a nitrogen-containing bisphosphonate, on calcium-activated potassium channels in Madin-Darby canine kidney cells.

Sheng-Nan Wu, Hui-Zhen Chen, Yu-Hung Chou, Yan-Ming Huang, Yi-Ching Lo

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Evidence for Effective Multiple KFrontiers in pharmacology · 2019
    Article
  4. The native TRPP2-dependent channel of murine renal primary cilia.American journal of physiology. Renal physiology · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Sheng-Nan WuDepartment of Physiology, National Cheng Kung University Medical College, Tainan City, Taiwan.
Hui-Zhen ChenDepartment of Physiology, National Cheng Kung University Medical College, Tainan City, Taiwan.
Yu-Hung ChouSchool of Medicine, Mayne Medical School, University of Queensland, Brisbane, Queensland, Australia.
Yan-Ming HuangDepartment of Physiology, National Cheng Kung University Medical College, Tainan City, Taiwan.
Yi-Ching LoDepartment of Pharmacology, Kaohsiung Medical University, Kaohsiung City, Taiwan.
National Cheng Kung University · TWKaohsiung Medical University · TWUniversity of Queensland · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The nitrogen-containing bisphosphonates used for management of the patients with osteoporosis were reported to influence the function of renal tubular cells. However, how nitrogen-containing bisphosphates exert any effects on ion currents remains controversial. The effects of ibandronate (Iban), a nitrogen-containing bisphosphonate, on ionic channels, including two types of Ca

Indexed as

BKCa channel, large-conductance Ca2+-activated K+ channel[Ca2+]i, intracellular Ca2+ concentrationDC-EBIO, 5,6-dichloro-1-ethyl-1,3-dihydro-2H-benzimidazol-2-oneDMEM, Dulbecco’s modified Eagle’s mediumFBS, fetal bovine serumH2S, hydrogen sulfideIbandronateIban, ibandronate sodiumIKCa channel, intermediate-conductance Ca2+-activated K+ channelIK, voltage-gated K+ currentIntermediate-conductance Ca2+-activated K+ channelI–V, current–voltageKCa channel, Ca2+-activated K+ channelKD, dissociation constantLarge-conductance Ca2+-activated K+ channelMDCK cellMDCK cell, Madin–Darby canine kidney cell,NaHS, sodium hydrosulphideMembrane potentialPF573228, 3,4-dihydro-6-[[4-[[[3-(methylsulfonyl)phenyl]methyl]amino]-5(trifluoromethyl)-2-pyrimidinyl]amino]-2(1H)-quinolinoneSEM, standard error of the meanTRAM-34, 1-((2-chloropheny) (diphenyl)methyl)-1H-pyrazole

Identifiers

PMID28962460
PMCPMC5598360
OpenAlexW1613470357

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.