Evidence map›Paper›PMID 28962432›Full record

ArticleToxicology reports2015

Erectile dysfunction drugs and oxidative stress in the liver of male rats.

Salah Sheweita, Basant Salama, Mostafa Hassan

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Toxicology reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Comparative efficacy of Gum Arabic (Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2020
    Article
  6. Review
  7. Article
  8. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Salah SheweitaDepartment of Biotechnology, Institute of Graduate Studies & Research, Alexandria University, Egypt.
Basant SalamaDepartment of Biotechnology, Institute of Graduate Studies & Research, Alexandria University, Egypt.
Mostafa HassanDepartment of Environmental Studies, Institute of Graduate Studies & Research, Alexandria University, Egypt.
Alexandria University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Erectile dysfunction (ED) affected the lives of more than 300 million men worldwide. Erectile dysfunction drugs (EDD), known as phosphodiesterase inhibitors (PDEIs), have been used for treatment of ED. It has been shown that oxidative stress plays an important role in the progression of erectile dysfunction. Oxidative stress can be alleviated or decreased by antioxidant enzymes. Therefore, the present study aims at investigating the changes in the activity of antioxidant enzymes such as superoxide dismutase, catalase, and glutathione reductase as well as protein expression of glutathione peroxidase and glutathione

Indexed as

CatalaseCAT, catalaseEDD, erectile dysfunction drugsED, erectile dysfunctionGlutathioneGlutathione peroxidaseGlutathione reductaseGPx, glutathione peroxidaseGR, glutathione reductaseGSH, glutathioneGST, glutathione S-transferaseMDA, malondialdyhydeOxidative stressPDE-5, phosphodiesterase type-5PDEIs, phosphodiesterase inhibitorsROS, reactive oxygen speciesSOD, superoxide dismutase

Identifiers

PMID28962432
PMCPMC5598225
OpenAlexW2182233876

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.